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Dr. Carleen Eaton

Dr. Carleen Eaton

The Cell Cycle

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Table of Contents

Section 1: Chemistry of Life
Elements, Compounds, and Chemical Bonds

56m 18s

Intro
0:00
Elements
0:09
Elements
0:48
Matter
0:55
Naturally Occurring Elements
1:12
Atomic Number and Atomic Mass
2:39
Compounds
3:06
Molecule
3:07
Compounds
3:14
Examples
3:20
Atoms
4:53
Atoms
4:56
Protons, Neutrons, and Electrons
5:29
Isotopes
10:42
Energy Levels of Electrons
13:01
Electron Shells
13:13
Valence Shell
13:22
Example: Electron Shells and Potential Energy
13:28
Covalent Bonds
19:52
Covalent Bonds
19:54
Examples
20:03
Polar and Nonpolar Covalent Bonds
23:54
Polar Bond
24:07
Nonpolar Bonds
24:17
Examples
24:25
Ionic Bonds
29:04
Ionic Bond, Cations, Anions
29:19
Example: NaCl
29:30
Hydrogen Bond
33:18
Hydrogen Bond
33:20
Chemical Reactions
35:36
Example: Reactants, Products and Chemical Reactions
35:45
Molecular Mass and Molar Concentration
38:45
Avogadro's Number and Mol
39:12
Examples: Molecular Mass and Molarity
42:10
Example 1: Proton, Neutrons and Electrons
47:05
Example 2: Reactants and Products
49:35
Example 3: Bonding
52:39
Example 4: Mass
53:59
Properties of Water

50m 23s

Intro
0:00
Molecular Structure of Water
0:21
Molecular Structure of Water
0:27
Properties of Water
4:30
Cohesive
4:55
Transpiration
5:29
Adhesion
6:20
Surface Tension
7:17
Properties of Water, cont.
9:14
Specific Heat
9:25
High Heat Capacity
13:24
High Heat of Evaporation
16:42
Water as a Solvent
21:13
Solution
21:28
Solvent
21:48
Example: Water as a Solvent
22:22
Acids and Bases
25:40
Example
25:41
pH
36:30
pH Scale: Acidic, Neutral, and Basic
36:35
Example 1: Molecular Structure and Properties of Water
41:18
Example 2: Special Properties of Water
42:53
Example 3: pH Scale
44:46
Example 4: Acids and Bases
46:19
Organic Compounds

53m 54s

Intro
0:00
Organic Compounds
0:09
Organic Compounds
0:11
Inorganic Compounds
0:15
Examples: Organic Compounds
1:15
Isomers
5:52
Isomers
5:55
Structural Isomers
6:23
Geometric Isomers
8:14
Enantiomers
9:55
Functional Groups
12:46
Examples: Functional Groups
12:59
Amino Group
13:51
Carboxyl Group
14:38
Hydroxyl Group
15:22
Methyl Group
16:14
Carbonyl Group
16:30
Phosphate Group
17:51
Carbohydrates
18:26
Carbohydrates
19:07
Example: Monosaccharides
21:12
Carbohydrates, cont.
24:11
Disaccharides, Polysaccharides and Examples
24:21
Lipids
35:52
Examples of Lipids
36:04
Saturated and Unsaturated
38:57
Phospholipids
43:26
Phospholipids
43:29
Example
43:34
Steroids
46:24
Cholesterol
46:28
Example 1: Isomers
48:11
Example 2: Functional Groups
50:45
Example 3: Galactose, Ketose, and Aldehyde Sugar
52:24
Example 4: Class of Molecules
53:06
Nucleic Acids and Proteins

37m 23s

Intro
0:00
Nucleic Acids
0:09
Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA)
0:29
Nucleic Acids, cont.
2:56
Purines
3:10
Pyrimidines
3:32
Double Helix
4:59
Double Helix and Example
5:01
Proteins
12:33
Amino Acids and Polypeptides
12:39
Examples: Amino Acid
13:25
Polypeptide Formation
18:09
Peptide Bonds
18:14
Primary Structure
18:35
Protein Structure
23:19
Secondary Structure
23:22
Alpha Helices and Beta Pleated Sheets
23:34
Protein Structure
25:43
Tertiary Structure
25:44
5 Types of Interaction
26:56
Example 1: Complementary DNA Strand
31:45
Example 2: Differences Between DNA and RNA
33:19
Example 3: Amino Acids
34:32
Example 4: Tertiary Structure of Protein
35:46
Section 2: Cell Structure and Function
Cell Types (Prokaryotic and Eukaryotic)

45m 50s

Intro
0:00
Cell Theory and Cell Types
0:12
Cell Theory
0:13
Prokaryotic and Eukaryotic Cells
0:36
Endosymbiotic Theory
1:13
Study of Cells
4:07
Tools and Techniques
4:08
Light Microscopes
5:08
Light vs. Electron Microscopes: Magnification
5:18
Light vs. Electron Microscopes: Resolution
6:26
Light vs. Electron Microscopes: Specimens
7:53
Electron Microscopes: Transmission and Scanning
8:28
Cell Fractionation
10:01
Cell Fractionation Step 1: Homogenization
10:33
Cell Fractionation Step 2: Spin
11:24
Cell Fractionation Step 3: Differential Centrifugation
11:53
Comparison of Prokaryotic and Eukaryotic Cells
14:12
Prokaryotic vs. Eukaryotic Cells: Domains
14:43
Prokaryotic vs. Eukaryotic Cells: Plasma Membrane
15:40
Prokaryotic vs. Eukaryotic Cells: Cell Walls
16:15
Prokaryotic vs. Eukaryotic Cells: Genetic Materials
16:38
Prokaryotic vs. Eukaryotic Cells: Structures
17:28
Prokaryotic vs. Eukaryotic Cells: Unicellular and Multicellular
18:19
Prokaryotic vs. Eukaryotic Cells: Size
18:31
Plasmids
18:52
Prokaryotic vs. Eukaryotic Cells
19:22
Nucleus
19:24
Organelles
19:48
Cytoskeleton
20:02
Cell Wall
20:35
Ribosomes
20:57
Size
21:37
Comparison of Plant and Animal Cells
22:15
Plasma Membrane
22:55
Plant Cells Only: Cell Walls
23:12
Plant Cells Only: Central Vacuole
25:08
Animal Cells Only: Centrioles
26:40
Animal Cells Only: Lysosomes
27:43
Plant vs. Animal Cells
29:16
Overview of Plant and Animal Cells
29:17
Evidence for the Endosymbiotic Theory
30:52
Characteristics of Mitochondria and Chloroplasts
30:54
Example 1: Prokaryotic vs. Eukaryotic Cells
35:44
Example 2: Endosymbiotic Theory and Evidence
38:38
Example 3: Plant and Animal Cells
41:49
Example 4: Cell Fractionation
43:44
Subcellular Structure

59m 38s

Intro
0:00
Prokaryotic Cells
0:09
Shapes of Prokaryotic Cells
0:22
Cell Wall
1:19
Capsule
3:23
Pili/Fimbria
3:54
Flagella
4:35
Nucleoid
6:16
Plasmid
6:37
Ribosomes
7:09
Eukaryotic Cells (Animal Cell Structure)
8:01
Plasma Membrane
8:13
Microvilli
8:48
Nucleus
9:47
Nucleolus
11:06
Ribosomes: Free and Bound
12:26
Rough Endoplasmic Reticulum (RER)
13:43
Eukaryotic Cells (Animal Cell Structure), cont.
14:51
Endoplasmic Reticulum: Smooth and Rough
15:08
Golgi Apparatus
17:55
Vacuole
20:43
Lysosome
22:01
Mitochondria
25:40
Peroxisomes
28:18
Cytoskeleton
30:41
Cytoplasm and Cytosol
30:53
Microtubules: Centrioles, Spindel Fibers, Clagell, Cillia
32:06
Microfilaments
36:39
Intermediate Filaments and Kerotin
38:52
Eukaryotic Cells (Plant Cell Structure)
40:08
Plasma Membrane, Primary Cell Wall, and Secondary Cell Wall
40:30
Middle Lamella
43:21
Central Cauole
44:12
Plastids: Leucoplasts, Chromoplasts, Chrloroplasts
45:35
Chloroplasts
47:06
Example 1: Structures and Functions
48:46
Example 2: Cell Walls
51:19
Example 3: Cytoskeleton
52:53
Example 4: Antibiotics and the Endosymbiosis Theory
56:55
Cell Membranes and Transport

53m 10s

Intro
0:00
Cell Membrane Structure
0:09
Phospholipids Bilayer
0:11
Chemical Structure: Amphipathic and Fatty Acids
0:25
Cell Membrane Proteins
2:44
Fluid Mosaic Model
2:45
Peripheral Proteins and Integral Proteins
3:19
Transmembrane Proteins
4:34
Cholesterol
4:48
Functions of Membrane Proteins
6:39
Transport Across Cell Membranes
9:52
Transport Across Cell Membranes
9:53
Methods of Passive Transport
12:07
Passive and Active Transport
12:08
Simple Diffusion
12:45
Facilitated Diffusion
15:20
Osmosis
17:17
Definition and Example of Osmosis
17:18
Hypertonic, Hypotonic, and Isotonic
21:47
Active Transport
27:57
Active Transport
28:17
Sodium and Potassium Pump
29:45
Cotransport
34:38
2 Types of Active Transport
37:09
Endocytosis and Exocytosis
37:38
Endocytosis and Exocytosis
37:51
Types of Endocytosis: Pinocytosis
40:39
Types of Endocytosis: Phagocytosis
41:02
Receptor Mediated Endocytosis
41:27
Receptor Mediated Endocytosis
41:28
Example 1: Cell Membrane and Permeable Substances
43:59
Example 2: Osmosis
45:20
Example 3: Active Transport, Cotransport, Simple and Facilitated Diffusion
47:36
Example 4: Match Terms with Definition
50:55
Cellular Communication

57m 9s

Intro
0:00
Extracellular Matrix
0:28
The Extracellular Matrix (ECM)
0:29
ECM in Animal Cells
0:55
Fibronectin and Integrins
1:34
Intercellular Communication in Plants
2:48
Intercellular Communication in Plants: Plasmodesmata
2:50
Cell to Cell Communication in Animal Cells
3:39
Cell Junctions
3:42
Desmosomes
3:54
Tight Junctions
5:07
Gap Junctions
7:00
Cell Signaling
8:17
Cell Signaling: Ligand and Signal Transduction Pathway
8:18
Direct Contact
8:48
Over Distances Contact and Hormones
10:09
Stages of Cell Signaling
11:53
Reception Phase
11:54
Transduction Phase
13:49
Response Phase
14:45
Cell Membrane Receptors
15:37
G-Protein Coupled Receptor
15:38
Cell Membrane Receptor, Cont.
21:37
Receptor Tyrosine Kinases (RTKs)
21:38
Autophosphorylation, Monomer, and Dimer
22:57
Cell Membrane Receptor, Cont.
27:01
Ligand-Gated Ion Channels
27:02
Intracellular Receptors
29:43
Intracellular Receptor and Receptor -Ligand Complex
29:44
Signal Transduction
32:57
Signal Transduction Pathways
32:58
Adenylyl Cyclase and cAMP
35:53
Second Messengers
39:18
cGMP, Inositol Trisphosphate, and Diacylglycerol
39:20
Cell Response
45:15
Cell Response
45:16
Apoptosis
46:57
Example 1: Tight Junction and Gap Junction
48:29
Example 2: Three Phases of Cell Signaling
51:48
Example 3: Ligands and Binding of Hormone
54:03
Example 4: Signal Transduction
56:06
Section 3: Cell Division
The Cell Cycle

37m 49s

Intro
0:00
Functions of Cell Division
0:09
Overview of Cell Division: Reproduction, Growth, and Repair
0:11
Important Term: Daughter Cells
2:25
Chromosome Structure
3:36
Chromosome Structure: Sister Chromatids and Centromere
3:37
Chromosome Structure: Chromatin
4:31
Chromosome with One Chromatid or Two Chromatids
5:25
Chromosome Structure: Long and Short Arm
6:49
Mitosis and Meiosis
7:00
Mitosis
7:41
Meiosis
8:40
The Cell Cycle
10:43
Mitotic Phase and Interphase
10:44
Cytokinesis
15:51
Cytokinesis in Animal Cell: Cleavage Furrow
15:52
Cytokinesis in Plant Cell: Cell Plate
17:28
Control of the Cell Cycle
18:28
Cell Cycle Control System and Checkpoints
18:29
Cyclins and Cyclin Dependent Kinases
21:18
Cyclins and Cyclin Dependent Kinases (CDKSs)
21:20
MPF
23:17
Internal Factor Regulating Cell Cycle
24:00
External Factor Regulating Cell Cycle
24:53
Contact Inhibition and Anchorage Dependent
25:53
Cancer and the Cell Cycle
27:42
Cancer Cells
27:46
Example1: Parts of the Chromosome
30:15
Example 2: Cell Cycle
31:50
Example 3: Control of the Cell Cycle
33:32
Example 4: Cancer and the Cell
35:01
Mitosis

35m 1s

Intro
0:00
Review of the Cell Cycle
0:09
Interphase: G1 Phase
0:34
Interphase: S Phase
0:56
Interphase: G2 Phase
1:31
M Phase: Mitosis and Cytokinesis
1:47
Overview of Mitosis
3:08
What is Mitosis?
3:10
Overview of Mitosis
3:17
Diploid and Haploid
5:37
Homologous Chromosomes
6:04
The Spindle Apparatus
11:57
The Spindle Apparatus
12:00
Centrosomes and Centrioles
12:40
Microtubule Organizing Center
13:03
Spindle Fiber of Spindle Microtubules
13:23
Kinetochores
14:06
Asters
15:45
Prophase
16:47
First Phase of Mitosis: Prophase
16:54
Metaphase
20:05
Second Phase of Mitosis: Metaphase
20:10
Anaphase
22:52
Third Phase of Mitosis: Anaphase
22:53
Telophase and Cytokinesis
24:34
Last Phase of Mitosis: Telophase and Cytokinesis
24:35
Summary of Mitosis
27:46
Summary of Mitosis
27:47
Example 1: Spindle Apparatus
28:50
Example 2: Last Phase of Mitosis
30:39
Example 3: Prophase
32:41
Example 4: Identify the Phase
33:52
Meiosis

1h 58s

Intro
0:00
Haploid and Diploid Cells
0:09
Diploid and Somatic Cells
0:29
Haploid and Gametes
1:20
Example: Human Cells and Chromosomes
1:41
Sex Chromosomes
6:00
Comparison of Mitosis and Meiosis
10:42
Mitosis Vs. Meiosis: Cell Division
10:59
Mitosis Vs. Meiosis: Daughter Cells
12:31
Meiosis: Pairing of Homologous Chromosomes
13:40
Mitosis and Meiosis
14:21
Process of Mitosis
14:27
Process of Meiosis
16:12
Synapsis and Crossing Over
19:14
Prophase I: Synapsis and Crossing Over
19:15
Chiasmata
22:33
Meiosis I
25:49
Prophase I: Crossing Over
25:50
Metaphase I: Homologs Line Up
26:00
Anaphase I: Homologs Separate
28:16
Telophase I and Cytokinesis
29:15
Independent Assortment
30:58
Meiosis II
32:17
Propphase II
33:50
Metaphase II
34:06
Anaphase II
34:50
Telophase II
36:09
Cytokinesis
37:00
Summary of Meiosis
38:15
Summary of Meiosis
38:16
Cell Division Mechanism in Plants
41:57
Example 1: Cell Division and Meiosis
46:15
Example 2: Phases of Meiosis
50:22
Example 3: Label the Figure
54:29
Example 4: Four Differences Between Mitosis and Meiosis
56:37
Section 4: Cellular Energetics
Enzymes

51m 3s

Intro
0:00
Law of Thermodynamics
0:08
Thermodynamics
0:09
The First Law of Thermodynamics
0:37
The Second Law of Thermodynamics
1:24
Entropy
1:35
The Gibbs Free Energy Equation
3:07
The Gibbs Free Energy Equation
3:08
ATP
8:23
Adenosine Triphosphate (ATP)
8:24
Cellular Respiration
11:32
Catabolic Pathways
12:28
Anabolic Pathways
12:54
Enzymes
14:31
Enzymes
14:32
Enzymes and Exergonic Reaction
14:40
Enzymes and Endergonic Reaction
16:36
Enzyme Specificity
21:29
Substrate
21:41
Induced Fit
23:04
Factors Affecting Enzyme Activity
25:55
Substrate Concentration
26:07
pH
27:10
Temperature
29:14
Presence of Cofactors
29:57
Regulation of Enzyme Activity
31:12
Competitive Inhibitors
32:13
Noncompetitive Inhibitors
33:52
Feedback Inhibition
35:22
Allosteric Interactions
36:56
Allosteric Regulators
37:00
Example 1: Is the Inhibitor Competitive or Noncompetitive?
40:49
Example 2: Thermophiles
44:18
Example 3: Exergonic or Endergonic
46:09
Example 4: Energy Vs. Reaction Progress Graph
48:47
Glycolysis and Anaerobic Respiration

38m 1s

Intro
0:00
Cellular Respiration Overview
0:13
Cellular Respiration
0:14
Anaerobic Respiration vs. Aerobic Respiration
3:50
Glycolysis Overview
4:48
Overview of Glycolysis
4:50
Glycolysis Involves a Redox Reaction
7:02
Redox Reaction
7:04
Glycolysis
15:04
Important Facts About Glycolysis
15:07
Energy Invested Phase
16:12
Splitting of Fructose 1,6-Phosphate and Energy Payoff Phase
17:50
Substrate Level Phophorylation
22:12
Aerobic Versus Anaerobic Respiration
23:57
Aerobic Versus Anaerobic Respiration
23:58
Cellular Respiration Overview
27:15
When Cellular Respiration is Anaerobic
27:17
Glycolysis
28:26
Alcohol Fermentation
28:45
Lactic Acid Fermentation
29:58
Example 1: Glycolysis
31:04
Example 2: Glycolysis, Fermentation and Anaerobic Respiration
33:44
Example 3: Aerobic Respiration Vs. Anaerobic Respiration
35:25
Example 4: Exergonic Reaction and Endergonic Reaction
36:42
Aerobic Respiration

51m 6s

Intro
0:00
Aerobic Vs. Anaerobic Respiration
0:06
Aerobic and Anaerobic Comparison
0:07
Review of Glycolysis
1:48
Overview of Glycolysis
2:06
Glycolysis: Energy Investment Phase
2:25
Glycolysis: Energy Payoff Phase
2:58
Conversion of Pyruvate to Acetyl CoA
4:55
Conversion of Pyruvate to Acetyl CoA
4:56
Energy Formation
8:06
Mitochondrial Structure
8:58
Endosymbiosis Theory
9:23
Matrix
10:00
Outer Membrane, Inner Membrane, and Intermembrane Space
10:43
Cristae
11:47
The Citric Acid Cycle
12:11
The Citric Acid Cycle (Also Called Krebs Cycle)
12:12
Substrate Level Phosphorylation
18:47
Summary of ATP, NADH, and FADH2 Production
23:13
Process: Glycolysis
23:28
Process: Acetyl CoA Production
23:36
Process: Citric Acid Cycle
23:52
The Electron Transport Chain
24:24
Oxidative Phosphorylation
24:28
The Electron Transport Chain and ATP Synthase
25:20
Carrier Molecules: Cytochromes
27:18
Carrier Molecules: Flavin Mononucleotide (FMN)
28:05
Chemiosmosis
32:46
The Process of Chemiosmosis
32:47
Summary of ATP Produced by Aerobic Respiration
38:24
ATP Produced by Aerobic Respiration
38:27
Example 1: Aerobic Respiration
43:38
Example 2: Label the Location for Each Process and Structure
45:08
Example 3: The Electron Transport Chain
47:06
Example 4: Mitochondrial Inner Membrane
48:38
Photosynthesis

1h 2m 52s

Intro
0:00
Photosynthesis
0:09
Introduction to Photosynthesis
0:10
Autotrophs and Heterotrophs
0:25
Overview of Photosynthesis Reaction
1:05
Leaf Anatomy and Chloroplast Structure
2:54
Chloroplast
2:55
Cuticle
3:16
Upper Epidermis
3:27
Mesophyll
3:40
Stomates
4:00
Guard Cells
4:45
Transpiration
5:01
Vascular Bundle
5:20
Stroma and Double Membrane
6:20
Grana
7:17
Thylakoids
7:30
Dark Reaction and Light Reaction
7:46
Light Reactions
8:43
Light Reactions
8:47
Pigments: Chlorophyll a, Chlorophyll b, and Carotenoids
9:19
Wave and Particle
12:10
Photon
12:34
Photosystems
13:24
Photosystems
13:28
Reaction-Center Complex and Light Harvesting Complexes
14:01
Noncyclic Photophosphorylation
17:46
Noncyclic Photophosphorylation Overview
17:47
What is Photophosphorylation?
18:25
Noncyclic Photophosphorylation Process
19:07
Photolysis and The Rest of Noncyclic Photophosphorylation
21:33
Cyclic Photophosphorylation
31:45
Cyclic Photophosphorylation
31:46
Light Independent Reactions
34:34
The Calvin Cycle
34:35
C3 Plants and Photorespiration
40:31
C3 Plants and Photorespiration
40:32
C4 Plants
45:32
C4 Plants: Structures and Functions
45:33
CAM Plants
50:25
CAM Plants: Structures and Functions
50:35
Example 1: Calvin Cycle
54:34
Example 2: C4 Plant
55:48
Example 3: Photosynthesis and Photorespiration
58:35
Example 4: CAM Plants
1:00:41
Section 5: Molecular Genetics
DNA Synthesis

38m 45s

Intro
0:00
Review of DNA Structure
0:09
DNA Molecules
0:10
Nitrogenous Base: Pyrimidines and Purines
1:25
DNA Double Helix
3:03
Complementary Strands of DNA
3:12
5' to 3' & Antiparallel
4:55
Overview of DNA Replication
7:10
DNA Replication & Semiconservative
7:11
DNA Replication
10:26
Origin of Replication
10:28
Helicase
11:10
Single-Strand Binding Protein
12:05
Topoisomerases
13:14
DNA Polymerase
14:26
Primase
15:55
Leading and Lagging Strands
16:51
Leading Strand and Lagging Strand
16:52
Okazaki Fragments
18:10
DNA Polymerase I
20:11
Ligase
21:12
Proofreading and Mismatch Repair
22:18
Proofreading
22:19
Mismatch
23:33
Telomeres
24:58
Telomeres
24:59
Example 1: Function of Enzymes During DNA Synthesis
28:09
Example 2: Accuracy of the DNA Sequence
31:42
Example 3: Leading Strand and Lagging Strand
32:38
Example 4: Telomeres
35:40
Transcription and Translation

1h 17m 1s

Intro
0:00
Transcription and Translation Overview
0:07
From DNA to RNA to Protein
0:09
Structure and Types of RNA
3:14
Structure and Types of RNA
3:33
mRNA
6:19
rRNA
7:02
tRNA
7:28
Transcription
7:54
Initiation Phase
8:11
Elongation Phase
12:12
Termination Phase
14:51
RNA Processing
16:11
Types of RNA Processing
16:12
Exons and Introns
16:35
Splicing & Spliceosomes
18:27
Addition of a 5' Cap and a Poly A tail
20:41
Alternative Splicing
21:43
Translation
23:41
Nucleotide Triplets or Codons
23:42
Start Codon
25:24
Stop Codons
25:38
Coding of Amino Acids and Wobble Position
25:57
Translation Cont.
28:29
Transfer RNA (tRNA): Structures and Functions
28:30
Ribosomes
35:15
Peptidyl, Aminoacyl, and Exit Site
35:23
Steps of Translation
36:58
Initiation Phase
37:12
Elongation Phase
43:12
Termination Phase
45:28
Mutations
49:43
Types of Mutations
49:44
Substitutions: Silent
51:11
Substitutions: Missense
55:27
Substitutions: Nonsense
59:37
Insertions and Deletions
1:01:10
Example 1: Three Types of Processing that are Performed on pre-mRNA
1:06:53
Example 2: The Process of Translation
1:09:10
Example 3: Transcription
1:12:04
Example 4: Three Types of Substitution Mutations
1:14:09
Viral Structure and Genetics

43m 12s

Intro
0:00
Structure of Viruses
0:09
Structure of Viruses: Capsid and Envelope
0:10
Bacteriophage
1:48
Other Viruses
2:28
Overview of Viral Reproduction
3:15
Host Range
3:48
Step 1: Bind to Host Cell
4:39
Step 2: Viral Nuclei Acids Enter the Cell
5:15
Step 3: Viral Nucleic Acids & Proteins are Synthesized
5:54
Step 4: Virus Assembles
6:34
Step 5: Virus Exits the Cell
6:55
The Lytic Cycle
7:37
Steps in the Lytic Cycle
7:38
The Lysogenic Cycle
11:27
Temperate Phage
11:34
Steps in the Lysogenic Cycle
12:09
RNA Viruses
16:57
Types of RNA Viruses
17:15
Positive Sense
18:16
Negative Sense
18:48
Reproductive Cycle of RNA Viruses
19:32
Retroviruses
25:48
Complementary DNA (cDNA) & Reverse Transcriptase
25:49
Life Cycle of a Retrovirus
28:22
Prions
32:42
Prions: Definition and Examples
32:45
Viroids
34:46
Example 1: The Lytic Cycle
35:37
Example 2: Retrovirus
38:03
Example 3: Positive Sense RNA vs. Negative Sense RNA
39:10
Example 4: The Lysogenic Cycle
40:42
Bacterial Genetics and Gene Regulation

49m 45s

Intro
0:00
Bacterial Genomes
0:09
Structure of Bacterial Genomes
0:16
Transformation
1:22
Transformation
1:23
Vector
2:49
Transduction
3:32
Process of Transduction
3:38
Conjugation
8:06
Conjugation & F factor
8:07
Operons
14:02
Definition and Example of Operon
14:52
Structural Genes
16:23
Promoter Region
17:04
Regulatory Protein & Operators
17:53
The lac Operon
20:09
The lac Operon: Inducible System
20:10
The trp Operon
28:02
The trp Operon: Repressible System
28:03
Corepressor
31:37
Anabolic & Catabolic
33:12
Positive Regulation of the lac Operon
34:39
Positive Regulation of the lac Operon
34:40
Example 1: The Process of Transformation
39:07
Example 2: Operon & Terms
43:29
Example 3: Inducible lac Operon and Repressible trp Operon
45:15
Example 4: lac Operon
47:10
Eukaryotic Gene Regulation and Mobile Genetic Elements

54m 26s

Intro
0:00
Mechanism of Gene Regulation
0:11
Differential Gene Expression
0:13
Levels of Regulation
2:24
Chromatin Structure and Modification
4:35
Chromatin Structure
4:36
Levels of Packing
5:50
Euchromatin and Heterochromatin
8:58
Modification of Chromatin Structure
9:58
Epigenetic
12:49
Regulation of Transcription
14:20
Promoter Region, Exon, and Intron
14:26
Enhancers: Control Element
15:31
Enhancer & DNA-Bending Protein
17:25
Coordinate Control
21:23
Silencers
23:01
Post-Transcriptional Regulation
24:05
Post-Transcriptional Regulation
24:07
Alternative Splicing
27:19
Differences in mRNA Stability
28:02
Non-Coding RNA Molecules: micro RNA & siRNA
30:01
Regulation of Translation and Post-Translational Modifications
32:31
Regulation of Translation and Post-Translational Modifications
32:55
Ubiquitin
35:21
Proteosomes
36:04
Transposons
37:50
Mobile Genetic Elements
37:56
Barbara McClintock
38:37
Transposons & Retrotransposons
40:38
Insertion Sequences
43:14
Complex Transposons
43:58
Example 1: Four Mechanisms that Decrease Production of Protein
45:13
Example 2: Enhancers and Gene Expression
49:09
Example 3: Primary Transcript
50:41
Example 4: Retroviruses and Retrotransposons
52:11
Biotechnology

49m 26s

Intro
0:00
Definition of Biotechnology
0:08
Biotechnology
0:09
Genetic Engineering
1:05
Example: Golden Corn
1:57
Recombinant DNA
2:41
Recombinant DNA
2:42
Transformation
3:24
Transduction
4:24
Restriction Enzymes, Restriction Sites, & DNA Ligase
5:32
Gene Cloning
13:48
Plasmids
14:20
Gene Cloning: Step 1
17:35
Gene Cloning: Step 2
17:57
Gene Cloning: Step 3
18:53
Gene Cloning: Step 4
19:46
Gel Electrophoresis
27:25
What is Gel Electrophoresis?
27:26
Gel Electrophoresis: Step 1
28:13
Gel Electrophoresis: Step 2
28:24
Gel Electrophoresis: Step 3 & 4
28:39
Gel Electrophoresis: Step 5
29:55
Southern Blotting
31:25
Polymerase Chain Reaction (PCR)
32:11
Polymerase Chain Reaction (PCR)
32:12
Denaturing Phase
35:40
Annealing Phase
36:07
Elongation/ Extension Phase
37:06
DNA Sequencing and the Human Genome Project
39:19
DNA Sequencing and the Human Genome Project
39:20
Example 1: Gene Cloning
40:40
Example 2: Recombinant DNA
43:04
Example 3: Match Terms With Descriptions
45:43
Example 4: Polymerase Chain Reaction
47:36
Section 6: Heredity
Mendelian Genetics

1h 32m 8s

Intro
0:00
Background
0:40
Gregory Mendel & Mendel's Law
0:41
Blending Hypothesis
1:04
Particulate Inheritance
2:08
Terminology
2:55
Gene
3:05
Locus
3:57
Allele
4:37
Dominant Allele
5:48
Recessive Allele
7:38
Genotype
9:22
Phenotype
10:01
Homozygous
10:44
Heterozygous
11:39
Penetrance
11:57
Expressivity
14:15
Mendel's Experiments
15:31
Mendel's Experiments: Pea Plants
15:32
The Law of Segregation
21:16
Mendel's Conclusions
21:17
The Law of Segregation
22:57
Punnett Squares
28:27
Using Punnet Squares
28:30
The Law of Independent Assortment
32:35
Monohybrid
32:38
Dihybrid
33:29
The Law of Independent Assortment
34:00
The Law of Independent Assortment, cont.
38:13
The Law of Independent Assortment: Punnet Squares
38:29
Meiosis and Mendel's Laws
43:38
Meiosis and Mendel's Laws
43:39
Test Crosses
49:07
Test Crosses Example
49:08
Probability: Multiplication Rule and the Addition Rule
53:39
Probability Overview
53:40
Independent Events & Multiplication Rule
55:40
Mutually Exclusive Events & Addition Rule
1:00:25
Incomplete Dominance, Codominance and Multiple Alleles
1:02:55
Incomplete Dominance
1:02:56
Incomplete Dominance, Codominance and Multiple Alleles
1:07:06
Codominance and Multiple Alleles
1:07:08
Polygenic Inheritance and Pleoitropy
1:10:19
Polygenic Inheritance and Pleoitropy
1:10:26
Epistasis
1:12:51
Example of Epistasis
1:12:52
Example 1: Genetic of Eye Color and Height
1:17:39
Example 2: Blood Type
1:21:57
Example 3: Pea Plants
1:25:09
Example 4: Coat Color
1:28:34
Linked Genes and Non-Mendelian Modes of Inheritance

39m 38s

Intro
0:00
Review of the Law of Independent Assortment
0:14
Review of the Law of Independent Assortment
0:24
Linked Genes
6:06
Linked Genes
6:07
Bateson & Pannett: Pea Plants
8:00
Crossing Over and Recombination
15:17
Crossing Over and Recombination
15:18
Extranuclear Genes
20:50
Extranuclear Genes
20:51
Cytoplasmic Genes
21:31
Genomic Imprinting
23:45
Genomic Imprinting
23:58
Methylation
24:43
Example 1: Recombination Frequencies & Linkage Map
27:07
Example 2: Linked Genes
28:39
Example 3: Match Terms to Correct Descriptions
36:46
Example 4: Leber's Optic Neuropathy
38:40
Sex-Linked Traits and Pedigree Analysis

43m 39s

Intro
0:00
Sex-Linked Traits
0:09
Human Chromosomes, XY, and XX
0:10
Thomas Morgan's Drosophila
1:44
X-Inactivation and Barr Bodies
14:48
X-Inactivation Overview
14:49
Calico Cats Example
17:04
Pedigrees
19:24
Definition and Example of Pedigree
19:25
Autosomal Dominant Inheritance
20:51
Example: Huntington's Disease
20:52
Autosomal Recessive Inheritance
23:04
Example: Cystic Fibrosis, Tay-Sachs Disease, and Phenylketonuria
23:05
X-Linked Recessive Inheritance
27:06
Example: Hemophilia, Duchene Muscular Dystrohpy, and Color Blindess
27:07
Example 1: Colorblind
29:48
Example 2: Pedigree
37:07
Example 3: Inheritance Pattern
39:54
Example 4: X-inactivation
41:17
Section 7: Evolution
Natural Selection

1h 3m 28s

Intro
0:00
Background
0:09
Work of Other Scientists
0:15
Aristotle
0:43
Carl Linnaeus
1:32
George Cuvier
2:47
James Hutton
4:10
Thomas Malthus
5:05
Jean-Baptiste Lamark
5:45
Darwin's Theory of Natural Selection
7:50
Evolution
8:00
Natural Selection
8:43
Charles Darwin & The Galapagos Islands
10:20
Genetic Variation
20:37
Mutations
20:38
Independent Assortment
21:04
Crossing Over
24:40
Random Fertilization
25:26
Natural Selection and the Peppered Moth
26:37
Natural Selection and the Peppered Moth
26:38
Types of Natural Selection
29:52
Directional Selection
29:55
Stabilizing Selection
32:43
Disruptive Selection
34:21
Sexual Selection
36:18
Sexual Dimorphism
37:30
Intersexual Selection
37:57
Intrasexual Selection
39:20
Evidence for Evolution
40:55
Paleontology: Fossil Record
41:30
Biogeography
45:35
Continental Drift
46:06
Pangaea
46:28
Marsupials
47:11
Homologous and Analogous Structure
50:10
Homologous Structure
50:12
Analogous Structure
53:21
Example 1: Genetic Variation & Natural Selection
56:15
Example 2: Types of Natural Selection
58:07
Example 3: Mechanisms By Which Genetic Variation is Maintained Within a Population
1:00:12
Example 4: Difference Between Homologous and Analogous Structures
1:01:28
Population Genetic and Evolution

53m 22s

Intro
0:00
Review of Natural Selection
0:12
Review of Natural Selection
0:13
Genetic Drift and Gene Flow
4:40
Definition of Genetic Drift
4:41
Example of Genetic Drift: Cholera Epidemic
5:15
Genetic Drift: Founder Effect
7:28
Genetic Drift: Bottleneck Effect
10:27
Gene Flow
13:00
Quantifying Genetic Variation
14:32
Average Heterozygosity
15:08
Nucleotide Variation
17:05
Maintaining Genetic Variation
18:12
Heterozygote Advantage
19:45
Example of Heterozygote Advantage: Sickle Cell Anemia
20:21
Diploidy
23:44
Geographic Variation
26:54
Frequency Dependent Selection and Outbreeding
28:15
Neutral Traits
30:55
The Hardy-Weinberg Equilibrium
31:11
The Hardy-Weinberg Equilibrium
31:49
The Hardy-Weinberg Conditions
32:42
The Hardy-Weinberg Equation
34:05
The Hardy-Weinberg Example
36:33
Example 1: Match Terms to Descriptions
42:28
Example 2: The Hardy-Weinberg Equilibrium
44:31
Example 3: The Hardy-Weinberg Equilibrium
49:10
Example 4: Maintaining Genetic Variation
51:30
Speciation and Patterns of Evolution

51m 2s

Intro
0:00
Early Life on Earth
0:08
Early Earth
0:09
1920's Oparin & Haldane
0:58
Abiogenesis
2:15
1950's Miller & Urey
2:45
Ribozymes
5:34
3.5 Billion Years Ago
6:39
2.5 Billion Years Ago
7:14
1.5 Billion Years Ago
7:41
Endosymbiosis
8:00
540 Million Years Ago: Cambrian Explosion
9:57
Gradualism and Punctuated Equilibrium
11:46
Gradualism
11:47
Punctuated Equilibrium
12:45
Adaptive Radiation
15:08
Adaptive Radiation
15:09
Example of Adaptive Radiation: Galapogos Islands
17:11
Convergent Evolution, Divergent Evolution, and Coevolution
18:30
Convergent Evolution
18:39
Divergent Evolution
21:30
Coevolution
23:49
Speciation
26:27
Definition and Example of Species
26:29
Reproductive Isolation: Prezygotive
27:49
Reproductive Isolation: Post zygotic
29:28
Allopatric Speciation
30:21
Allopatric Speciation & Geographic Isolation
30:28
Genetic Drift
31:31
Sympatric Speciation
34:10
Sympatric Speciation
34:11
Polyploidy & Autopolyploidy
35:12
Habitat Isolation
39:17
Temporal Isolation
41:27
Selection Selection
41:40
Example 1: Pattern of Evolution
42:53
Example 2: Sympatric Speciation
45:16
Example 3: Patterns of Evolution
48:08
Example 4: Patterns of Evolution
49:27
Section 8: Diversity of Life
Classification

1h 51s

Intro
0:00
Systems of Classification
0:07
Taxonomy
0:08
Phylogeny
1:04
Phylogenetics Tree
1:44
Cladistics
3:37
Classification of Organisms
5:31
Example of Carl Linnaeus System
5:32
Domains
9:26
Kingdoms: Monera, Protista, Plantae, Fungi, Animalia
9:27
Monera
10:06
Phylogentics Tree: Eurkarya, Bacteria, Archaea
11:58
Domain Eukarya
12:50
Domain Bacteria
15:43
Domain Bacteria
15:46
Pathogens
16:41
Decomposers
18:00
Domain Archaea
19:43
Extremophiles Archaea: Thermophiles and Halophiles
19:44
Methanogens
20:58
Phototrophs, Autotrophs, Chemotrophs and Heterotrophs
24:40
Phototrophs and Chemotrophs
25:02
Autotrophs and Heterotrophs
26:54
Photoautotrophs
28:50
Photoheterotrophs
29:28
Chemoautotrophs
30:06
Chemoheterotrophs
31:37
Domain Eukarya
32:40
Domain Eukarya
32:43
Plant Kingdom
34:28
Protists
35:48
Fungi Kingdom
37:06
Animal Kingdom
38:35
Body Symmetry
39:25
Lack Symetry
39:40
Radial Symmetry: Sea Aneome
40:15
Bilateral Symmetry
41:55
Cephalization
43:29
Germ Layers
44:54
Diploblastic Animals
45:18
Triploblastic Animals
45:25
Ectoderm
45:36
Endoderm
46:07
Mesoderm
46:41
Coelomates
47:14
Coelom
47:15
Acoelomate
48:22
Pseudocoelomate
48:59
Coelomate
49:31
Protosomes
50:46
Deuterosomes
51:20
Example 1: Domains
53:01
Example 2: Match Terms with Descriptions
56:00
Example 3: Kingdom Monera and Domain Archaea
57:50
Example 4: System of Classification
59:37
Bacteria

36m 46s

Intro
0:00
Comparison of Domain Archaea and Domain Bacteria
0:08
Overview of Archaea and Bacteria
0:09
Archaea vs. Bacteria: Nucleus, Organelles, and Organization of Genetic Material
1:45
Archaea vs. Bacteria: Cell Walls
2:20
Archaea vs. Bacteria: Number of Types of RNA Pol
2:29
Archaea vs. Bacteria: Membrane Lipids
2:53
Archaea vs. Bacteria: Introns
3:33
Bacteria: Pathogen
4:03
Bacteria: Decomposers and Fix Nitrogen
5:18
Bacteria: Aerobic, Anaerobic, Strict Anaerobes & Facultative Anaerobes
6:02
Phototrophs, Autotrophs, Heterotrophs and Chemotrophs
7:14
Phototrophs and Chemotrophs
7:50
Autotrophs and Heterotrophs
8:53
Photoautotrophs and Photoheterotrophs
10:15
Chemoautotroph and Chemoheterotrophs
11:07
Structure of Bacteria
12:21
Shapes: Cocci, Bacilli, Vibrio, and Spirochetes
12:26
Structures: Plasma Membrane and Cell Wall
14:23
Structures: Nucleoid Region, Plasmid, and Capsule Basal Apparatus, and Filament
15:30
Structures: Flagella, Basal Apparatus, Hook, and Filament
16:36
Structures: Pili, Fimbrae and Ribosome
18:00
Peptidoglycan: Gram + and Gram -
18:50
Bacterial Genomes and Reproduction
21:14
Bacterial Genomes
21:21
Reproduction of Bacteria
22:13
Transformation
23:26
Vector
24:34
Competent
25:15
Conjugation
25:53
Conjugation: F+ and R Plasmids
25:55
Example 1: Species
29:41
Example 2: Bacteria and Exchange of Genetic Material
32:31
Example 3: Ways in Which Bacteria are Beneficial to Other Organisms
33:48
Example 4: Domain Bacteria vs. Domain Archaea
34:53
Protists

1h 18m 48s

Intro
0:00
Classification of Protists
0:08
Classification of Protists
0:09
'Plant-like' Protists
2:06
'Animal-like' Protists
3:19
'Fungus-like' Protists
3:57
Serial Endosymbiosis Theory
5:15
Endosymbiosis Theory
5:33
Photosynthetic Protists
7:33
Life Cycles with a Diploid Adult
13:35
Life Cycles with a Diploid Adult
13:56
Life Cycles with a Haploid Adult
15:31
Life Cycles with a Haploid Adult
15:32
Alternation of Generations
17:22
Alternation of Generations: Multicellular Haploid & Diploid Phase
17:23
Plant-Like Protists
19:58
Euglenids
20:43
Dino Flagellates
22:57
Diatoms
26:07
Plant-Like Protists
28:44
Golden Algae
28:45
Brown Algeas
30:05
Plant-Like Protists
33:38
Red Algae
33:39
Green Algae
35:36
Green Algae: Chlamydomonus
37:44
Animal-Like Protists
40:04
Animal-Like Protists Overview
40:05
Sporozoans (Apicomplexans)
40:32
Alveolates
41:41
Sporozoans (Apicomplexans): Plasmodium & Malaria
42:59
Animal-Like Protists
48:44
Kinetoplastids
48:50
Example of Kinetoplastids: Trypanosomes & African Sleeping Sickness
49:30
Ciliate
50:42
Conjugation
53:16
Conjugation
53:26
Animal-Like Protists
57:08
Parabasilids
57:31
Diplomonads
59:06
Rhizopods
1:00:13
Forams
1:02:25
Radiolarians
1:03:28
Fungus-Like Protists
1:04:25
Fungus-Like Protists Overview
1:04:26
Slime Molds
1:05:15
Cellular Slime Molds: Feeding Stage
1:09:21
Oomycetes
1:11:15
Example 1: Alternation of Generations and Sexual Life Cycles
1:13:05
Example 2: Match Protists to Their Descriptions
1:14:12
Example 3: Three Structures that Protists Use for Motility
1:16:22
Example 4: Paramecium
1:17:04
Fungi

35m 24s

Intro
0:00
Introduction to Fungi
0:09
Introduction to Fungi
0:10
Mycologist
0:34
Examples of Fungi
0:45
Hyphae, Mycelia, Chitin, and Coencytic Fungi
2:26
Ancestral Protists
5:00
Role of Fungi in the Environment
5:35
Fungi as Decomposers
5:36
Mycorrrhiza
6:19
Lichen
8:52
Life Cycle of Fungi
11:32
Asexual Reproduction
11:33
Sexual Reproduction & Dikaryotic Cell
13:16
Chytridiomycota
18:12
Phylum Chytridiomycota
18:17
Zoospores
18:50
Zygomycota
19:07
Coenocytic & Zygomycota Life Cycle
19:08
Basidiomycota
24:27
Basidiomycota Overview
24:28
Basidiomycota Life Cycle
26:11
Ascomycota
28:00
Ascomycota Overview
28:01
Ascomycota Reproduction
28:50
Example 1: Fungi Fill in the Blank
31:02
Example 2: Name Two Roles Played by Fungi in the Environment
32:09
Example 3: Difference Between Diploid Cell and Dikaryon Cell
33:42
Example 4: Phylum of Fungi, Flagellated Spore, Coencytic
34:36
Invertebrates

1h 3m 3s

Intro
0:00
Porifera (Sponges)
0:33
Chordata
0:56
Porifera (Sponges): Sessile, Layers, Aceolomates, and Filter Feeders
1:24
Amoebocytes Cell
4:47
Choanocytes Cell
5:56
Sexual Reproduction
6:28
Cnidaria
8:05
Cnidaria Overview
8:06
Polyp & Medusa: Gastrovasular Cavity
8:29
Cnidocytes
9:42
Anthozoa
10:40
Cubozoa
11:23
Hydrozoa
11:53
Scyphoza
13:25
Platyhelminthes (Flatworms)
13:58
Flatworms: Tribloblastic, Bilateral Symmetry, and Cephalization
13:59
GI System
15:33
Excretory System
16:07
Nervous System
17:00
Turbellarians
17:36
Trematodes
18:42
Monageneans
21:32
Cestoda
21:55
Rotifera (Rotifers)
23:45
Rotifers: Digestive Tract, Pseudocoelem, and Stuctures
23:46
Reproduction: Parthenogenesis
25:33
Nematoda (Roundworms)
26:44
Nematoda (Roundworms)
26:45
Parasites: Pinworms & Hookworms
27:26
Annelida
28:36
Annelida Overview
28:37
Open Circulatory
29:21
Closed Circulatory
30:18
Nervous System
31:19
Excretory System
31:43
Oligochaete
32:07
Leeches
33:22
Polychaetes
34:42
Mollusca
35:26
Mollusca Features
35:27
Major Part 1: Visceral Mass
36:21
Major Part 2: Head-foot Region
36:49
Major Part 3: Mantle
37:13
Radula
37:49
Circulatory, Reproductive, Excretory, and Nervous System
38:14
Major Classes of Molluscs
39:12
Gastropoda
39:17
Polyplacophora
40:15
Bivales
40:41
Cephalopods
41:42
Arthropoda
43:35
Arthropoda Overview
43:36
Segmented Bodies
44:14
Exoskeleton
44:52
Jointed Appendages
45:28
Hemolyph, Excretory & Respiratory System
45:41
Myriapoda & Centipedes
47:15
Cheliceriforms
48:20
Crustcea
49:31
Herapoda
50:03
Echinodermata
52:59
Echinodermata
53:00
Watrer Vascular System
54:20
Selected Characteristics of Invertebrates
57:11
Selected Characteristics of Invertebrates
57:12
Example 1: Phylum Description
58:43
Example 2: Complex Animals
59:50
Example 3: Match Organisms to the Correct Phylum
1:01:03
Example 4: Phylum Arthropoda
1:02:01
Vertebrates

1h 7s

Intro
0:00
Phylum Chordata
0:06
Chordates Overview
0:07
Notochord and Dorsal Hollow Nerve Chord
1:24
Pharyngeal Clefts, Arches, and Post-anal Tail
3:41
Invertebrate Chordates
6:48
Lancelets
7:13
Tunicates
8:02
Hagfishes: Craniates
8:55
Vertebrate Chordates
10:41
Veterbrates Overview
10:42
Lampreys
11:00
Gnathostomes
12:20
Six Major Classes of Vertebrates
12:53
chondrichthyes
14:23
Chondrichthyes Overview
14:24
Ectothermic and Endothermic
14:42
Sharks: Lateral Line System, Neuromastsn, and Gills
15:27
Oviparous and Viviparous
17:23
Osteichthyes (Bony Fishes)
18:12
Osteichythes (Bony Fishes) Overview
18:13
Operculum
19:05
Swim Bladder
19:53
Ray-Finned Fishes
20:34
Lobe-Finned Fishes
20:58
Tetrapods
22:36
Tetrapods: Definition and Examples
22:37
Amphibians
23:53
Amphibians Overview
23:54
Order Urodela
25:51
Order Apoda
27:03
Order Anura
27:55
Reptiles
30:19
Reptiles Overview
30:20
Amniotes
30:37
Examples of Reptiles
32:46
Reptiles: Ectotherms, Gas Exchange, and Heart
33:40
Orders of Reptiles
34:17
Sphenodontia, Squamata, Testudines, and Crocodilia
34:21
Birds
36:09
Birds and Dinosaurs
36:18
Theropods
38:00
Birds: High Metabolism, Respiratory System, Lungs, and Heart
39:04
Birds: Endothermic, Bones, and Feathers
40:15
Mammals
42:33
Mammals Overview
42:35
Diaphragm and Heart
42:57
Diphydont
43:44
Synapsids
44:41
Monotremes
46:36
Monotremes
46:37
Marsupials
47:12
Marsupials: Definition and Examples
47:16
Convergent Evolution
48:09
Eutherians (Placental Mammals)
49:42
Placenta
49:43
Order Carnivora
50:48
Order Raodentia
51:00
Order Cetaceans
51:14
Primates
51:41
Primates Overview
51:42
Nails and Hands
51:58
Vision
52:51
Social Care for Young
53:28
Brain
53:43
Example 1: Distinguishing Characteristics of Chordates
54:33
Example 2: Match Description to Correct Term
55:56
Example 3: Bird's Anatomy
57:38
Example 4: Vertebrate Animal, Marine Environment, and Ectothermic
59:14
Section 9: Plants
Seedless Plants

34m 31s

Intro
0:00
Origin and Classification of Plants
0:06
Origin and Classification of Plants
0:07
Non-Vascular vs. Vascular Plants
1:29
Seedless Vascular & Seed Plants
2:28
Angiosperms & Gymnosperms
2:50
Alternation of Generations
3:54
Alternation of Generations
3:55
Bryophytes
7:58
Overview of Bryrophytes
7:59
Example: Moss Gametophyte
9:29
Example: Moss Sporophyte
9:50
Moss Life Cycle
10:12
Moss Life Cycle
10:13
Seedless Vascular Plants
13:23
Vascular Structures: Cell Walls, and Lignin
13:24
Homosporous
17:11
Heterosporous
17:48
Adaptations to Life on land
21:10
Adaptation 1: Cell Walls
21:38
Adaptation 2: Vascular Plants
21:59
Adaptation 3 : Xylem & Phloem
22:31
Adaptation 4: Seeds
23:07
Adaptation 5: Pollen
23:35
Adaptation 6: Stomata
24:45
Adaptation 7: Reduced Gametophyte Generation
25:32
Example 1: Bryophytes
26:39
Example 2: Sporangium, Lignin, Gametophyte, and Antheridium
28:34
Example 3: Adaptations to Life on Land
29:47
Example 4: Life Cycle of Plant
32:06
Plant Structure

1h 1m 21s

Intro
0:00
Plant Tissue
0:05
Dermal Tissue
0:15
Vascular Tissue
0:39
Ground Tissue
1:31
Cell Types in Plants
2:14
Parenchyma Cells
2:24
Collenchyma Cells
3:21
Sclerenchyma Cells
3:59
Xylem
5:04
Xylem: Tracheids and Vessel Elements
6:12
Gymnosperms vs. Angiosperms
7:53
Phloem
8:37
Phloem: Structures and Function
8:38
Sieve-Tube Elements
8:45
Companion Cells & Sieve Plates
9:11
Roots
10:08
Taproots & Fibrous
10:09
Aerial Roots & Prop Roots
11:41
Structures and Functions of Root: Dicot & Monocot
13:00
Pericyle
16:57
The Nitrogen Cylce
18:05
The Nitrogen Cycle
18:06
Mycorrhizae
24:20
Mycorrhizae
24:23
Ectomycorrhiza
26:03
Endomycorrhiza
26:25
Stems
26:53
Stems
26:54
Vascular Bundles of Monocots and Dicots
28:18
Leaves
29:48
Blade & Petiole
30:13
Upper Epidermis, Lower Epidermis & Cuticle
30:39
Ground Tissue, Palisade Mesophyll, Spongy Mesophyll
31:35
Stomata Pores
33:23
Guard Cells
34:15
Vascular Tissues: Vascular Bundles and Bundle Sheath
34:46
Stomata
36:12
Stomata & Gas Exchange
36:16
Guard Cells, Flaccid, and Turgid
36:43
Water Potential
38:03
Factors for Opening Stoma
40:35
Factors Causing Stoma to Close
42:44
Overview of Plant Growth
44:23
Overview of Plant Growth
44:24
Primary Plant Growth
46:19
Apical Meristems
46:25
Root Growth: Zone of Cell Division
46:44
Root Growth: Zone of Cell Elongation
47:35
Root Growth: Zone of Cell Differentiation
47:55
Stem Growth: Leaf Primodia
48:16
Secondary Plant Growth
48:48
Secondary Plant Growth Overview
48:59
Vascular Cambium: Secondary Xylem and Phloem
49:38
Cork Cambium: Periderm and Lenticels
51:10
Example 1: Leaf Structures
53:30
Example 2: List Three Types of Plant Tissue and their Major Functions
55:13
Example 3: What are Two Factors that Stimulate the Opening or Closing of Stomata?
56:58
Example 4: Plant Growth
59:18
Gymnosperms and Angiosperms

1h 1m 51s

Intro
0:00
Seed Plants
0:22
Sporopollenin
0:58
Heterosporous: Megasporangia
2:49
Heterosporous: Microsporangia
3:19
Gymnosperms
5:20
Gymnosperms
5:21
Gymnosperm Life Cycle
7:30
Gymnosperm Life Cycle
7:31
Flower Structure
15:15
Petal & Pollination
15:48
Sepal
16:52
Stamen: Anther, Filament
17:05
Pistill: Stigma, Style, Ovule, Ovary
17:55
Complete Flowers
20:14
Angiosperm Gametophyte Formation
20:47
Male Gametophyte: Microsporocytes, Microsporangia & Meiosis
20:57
Female Gametophyte: Megasporocytes & Meiosis
24:22
Double Fertilization
25:43
Double Fertilization: Pollen Tube and Endosperm
25:44
Angiosperm Life Cycle
29:43
Angiosperm Life Cycle
29:48
Seed Structure and Development
33:37
Seed Structure and Development
33:38
Pollen Dispersal
37:53
Abiotic
38:28
Biotic
39:30
Prevention of Self-Pollination
40:48
Mechanism 1
41:08
Mechanism 2: Dioecious
41:37
Mechanism 3
42:32
Self-Incompatibility
43:08
Gametophytic Self-Incompatibility
44:38
Sporophytic Self-Incompatibility
46:50
Asexual Reproduction
48:33
Asexual Reproduction & Vegetative Propagation
48:34
Graftiry
50:19
Monocots and Dicots
51:34
Monocots vs.Dicots
51:35
Example 1: Double Fertilization
54:43
Example 2: Mechanisms of Self-Fertilization
56:02
Example 3: Monocots vs. Dicots
58:11
Example 4: Flower Structures
1:00:11
Transport of Nutrients and Water in Plants

40m 30s

Intro
0:00
Review of Plant Cell Structure
0:14
Cell Wall, Plasma Membrane, Middle lamella, and Cytoplasm
0:15
Plasmodesmata, Chloroplasts, and Central Vacuole
3:24
Water Absorption by Plants
4:28
Root Hairs and Mycorrhizae
4:30
Osmosis and Water Potential
5:41
Apoplast and Symplast Pathways
10:01
Apoplast and Symplast Pathways
10:02
Xylem Structure
21:02
Tracheids and Vessel Elements
21:03
Bulk Flow
23:00
Transpiration
23:26
Cohesion
25:10
Adhesion
26:10
Phloem Structure
27:25
Pholem
27:26
Sieve-Tube Elements
27:48
Companion Cells
28:17
Translocation
28:42
Sugar Source and Sugar Sink Overview
28:43
Example of Sugar Sink
30:01
Example of Sugar Source
30:48
Example 1: Match the Following Terms to their Description
33:17
Example 2: Water Potential
34:58
Example 3: Bulk Flow
36:56
Example 4: Sugar Sink and Sugar Source
38:33
Plant Hormones and Tropisms

48m 10s

Intro
0:00
Plant Cell Signaling
0:17
Plant Cell Signaling Overview
0:18
Step 1: Reception
1:03
Step 2: Transduction
2:32
Step 3: Response
2:58
Second Messengers
3:52
Protein Kinases
4:42
Auxins
6:14
Auxins
6:18
Indoleacetic Acid (IAA)
7:23
Cytokinins and Gibberellins
11:10
Cytokinins: Apical Dominance & Delay of Aging
11:16
Gibberellins: 'Bolting'
13:51
Ethylene
15:33
Ethylene
15:34
Positive Feedback
15:46
Leaf Abscission
18:05
Mechanical Stress: Triple Response
19:36
Abscisic Acid
21:10
Abscisic Acid
21:15
Tropisms
23:11
Positive Tropism
23:50
Negative Tropism
24:07
Statoliths
26:21
Phytochromes and Photoperiodism
27:48
Phytochromes: PR and PFR
27:56
Circadian Rhythms
32:06
Photoperiod
33:13
Photoperiodism
33:38
Gerner & Allard
34:35
Short-Day Plant
35:22
Long-Day Plant
37:00
Example 1: Plant Hormones
41:28
Example 2: Cytokinins & Gibberellins
43:00
Example 3: Match the Following Terms to their Description
44:46
Example 4: Hormones & Cell Response
46:14
Section 10: Animal Structure and Physiology
The Respiratory System

48m 14s

Intro
0:00
Gas Exchange in Animals
0:17
Respiration
0:19
Ventilation
1:09
Characteristics of Respiratory Surfaces
1:53
Gas Exchange in Aquatic Animals
3:05
Simple Aquatic Animals
3:06
Gills & Gas Exchange in Complex Aquatic Animals
3:49
Countercurrent Exchange
6:12
Gas Exchange in Terrestrial Animals
13:46
Earthworms
14:07
Internal Respiratory
15:35
Insects
16:55
Circulatory Fluid
19:06
The Human Respiratory System
21:21
Nasal Cavity, Pharynx, Larynx, and Epiglottis
21:50
Bronchus, Bronchiole, Trachea, and Alveoli
23:38
Pulmonary Surfactants
28:05
Circulatory System: Hemoglobin
29:13
Ventilation
30:28
Inspiration/Expiration: Diaphragm, Thorax, and Abdomen
30:33
Breathing Control Center: Regulation of pH
34:34
Example 1: Tracheal System in Insects
39:08
Example 2: Countercurrent Exchange
42:09
Example 3: Respiratory System
44:10
Example 4: Diaphragm, Ventilation, pH, and Regulation of Breathing
45:31
The Circulatory System

1h 20m 21s

Intro
0:00
Types of Circulatory Systems
0:07
Circulatory System Overview
0:08
Open Circulatory System
3:19
Closed Circulatory System
5:58
Blood Vessels
7:51
Arteries
8:16
Veins
10:01
Capillaries
12:35
Vasoconstriction and Vasodilation
13:10
Vasoconstriction
13:11
Vasodilation
13:47
Thermoregulation
14:32
Blood
15:53
Plasma
15:54
Cellular Component: Red Blood Cells
17:41
Cellular Component: White Blood Cells
20:18
Platelets
21:14
Blood Types
21:35
Clotting
27:04
Blood, Fibrin, and Clotting
27:05
Hemophilia
30:26
The Heart
31:09
Structures and Functions of the Heart
31:19
Pulmonary and Systemic Circulation
40:20
Double Circuit: Pulmonary Circuit and Systemic Circuit
40:21
The Cardiac Cycle
42:35
The Cardiac Cycle
42:36
Autonomic Nervous System
50:00
Hemoglobin
51:25
Hemoglobin & Hemocyanin
51:26
Oxygen-Hemoglobin Dissociation Curve
55:30
Oxygen-Hemoglobin Dissociation Curve
55:44
Transport of Carbon Dioxide
1:06:31
Transport of Carbon Dioxide
1:06:37
Example 1: Pathway of Blood
1:12:48
Example 2: Oxygenated Blood, Pacemaker, and Clotting
1:15:24
Example 3: Vasodilation and Vasoconstriction
1:16:19
Example 4: Oxygen-Hemoglobin Dissociation Curve
1:18:13
The Digestive System

56m 11s

Intro
0:00
Introduction to Digestion
0:07
Digestive Process
0:08
Intracellular Digestion
0:45
Extracellular Digestion
1:44
Types of Digestive Tracts
2:08
Gastrovascular Cavity
2:09
Complete Gastrointestinal Tract (Alimentary Canal)
3:54
'Crop'
4:43
The Human Digestive System
5:41
Structures of the Human Digestive System
5:47
The Oral Cavity and Esophagus
7:47
Mechanical & Chemical Digestion
7:48
Salivary Glands
8:55
Pharynx and Epigloltis
9:43
Peristalsis
11:35
The Stomach
12:57
Lower Esophageal Sphincter
13:00
Gastric Gland, Parietal Cells, and Pepsin
14:32
Mucus Cell
15:48
Chyme & Pyloric Sphincter
17:32
The Pancreas
18:31
Endocrine and Exocrine
19:03
Amylase
20:05
Proteases
20:51
Lipases
22:20
The Liver
23:08
The Liver & Production of Bile
23:09
The Small Intestine
24:37
The Small Intestine
24:38
Duodenum
27:44
Intestinal Enzymes
28:41
Digestive Enzyme
33:30
Site of Production: Mouth
33:43
Site of Production: Stomach
34:03
Site of Production: Pancreas
34:16
Site of Production: Small Intestine
36:18
Absorption of Nutrients
37:51
Absorption of Nutrients: Jejunum and Ileum
37:52
The Large Intestine
44:52
The Large Intestine: Colon, Cecum, and Rectum
44:53
Regulation of Digestion by Hormones
46:55
Gastrin
47:21
Secretin
47:50
Cholecystokinin (CCK)
48:00
Example 1: Intestinal Cell, Bile, and Digestion of Fats
48:29
Example 2: Matching
51:06
Example 3: Digestion and Absorption of Starch
52:18
Example 4: Large Intestine and Gastric Fluids
54:52
The Excretory System

1h 12m 14s

Intro
0:00
Nitrogenous Wastes
0:08
Nitrogenous Wastes Overview
0:09
NH3
0:39
Urea
2:43
Uric Acid
3:31
Osmoregulation
4:56
Osmoregulation
5:05
Saltwater Fish vs. Freshwater Fish
8:58
Types of Excretory Systems
13:42
Protonephridia
13:50
Metanephridia
16:15
Malpighian Tubule
19:05
The Human Excretory System
20:45
Kidney, Ureter, bladder, Urethra, Medula, and Cortex
20:53
Filtration, Reabsorption and Secretion
22:53
Filtration
22:54
Reabsorption
24:16
Secretion
25:20
The Nephron
26:23
The Nephron
26:24
The Nephron, cont.
41:45
Descending Loop of Henle
41:46
Ascending Loop of Henle
45:45
Antidiuretic Hormone
54:30
Antidiuretic Hormone (ADH)
54:31
Aldosterone
58:58
Aldosterone
58:59
Example 1: Nephron of an Aquatic Mammal
1:04:21
Example 2: Uric Acid & Saltwater Fish
1:06:36
Example 3: Nephron
1:09:14
Example 4: Gastrointestinal Infection
1:10:41
The Endocrine System

51m 12s

Intro
0:00
The Endocrine System Overview
0:07
Thyroid
0:08
Exocrine
1:56
Pancreas
2:44
Paracrine Signaling
4:06
Pheromones
5:15
Mechanisms of Hormone Action
6:06
Reception, Transduction, and Response
7:06
Classes of Hormone
10:05
Negative Feedback: Testosterone Example
12:16
The Pancreas
15:11
The Pancreas & islets of Langerhan
15:12
Insulin
16:02
Glucagon
17:28
The Anterior Pituitary
19:25
Thyroid Stimulating Hormone
20:24
Adrenocorticotropic Hormone
21:16
Follide Stimulating Hormone
22:04
Luteinizing Hormone
22:45
Growth Hormone
23:45
Prolactin
24:24
Melanocyte Stimulating Hormone
24:55
The Hypothalamus and Posterior Pituitary
25:45
Hypothalamus, Oxytocin, Antidiuretic Hormone (ADH), and Posterior Pituitary
25:46
The Adrenal Glands
31:20
Adrenal Cortex
31:56
Adrenal Medulla
34:29
The Thyroid
35:54
Thyroxine
36:09
Calcitonin
40:27
The Parathyroids
41:44
Parathyroids Hormone (PTH)
41:45
The Ovaries and Testes
43:32
Estrogen, Progesterone, and Testosterone
43:33
Example 1: Match the Following Hormones with their Descriptions
45:38
Example 2: Pancreas, Endocrine Organ & Exocrine Organ
47:06
Example 3: Insulin and Glucagon
48:28
Example 4: Increased Level of Cortisol in Blood
50:25
The Nervous System

1h 10m 38s

Intro
0:00
Types of Nervous Systems
0:28
Nerve Net
0:37
Flatworm
1:07
Cephalization
1:52
Arthropods
2:44
Echinoderms
3:11
Nervous System Organization
3:40
Nervous System Organization Overview
3:41
Automatic Nervous System: Sympathetic & Parasympathetic
4:42
Neuron Structure
6:57
Cell Body & Dendrites
7:16
Axon & Axon Hillock
8:20
Synaptic Terminals, Mylenin, and Nodes of Ranvier
9:01
Pre-synaptic and Post-synaptic Cells
10:16
Pre-synaptic Cells
10:17
Post-synaptic Cells
11:05
Types of Neurons
11:50
Sensory Neurons
11:54
Motor Neurons
13:12
Interneurons
14:24
Resting Potential
15:14
Membrane Potential
15:25
Resting Potential: Chemical Gradient
16:06
Resting Potential: Electrical Gradient
19:18
Gated Ion Channels
24:40
Voltage-Gated & Ligand-Gated Ion Channels
24:48
Action Potential
30:09
Action Potential Overview
30:10
Step 1
32:07
Step 2
32:17
Step 3
33:12
Step 4
35:14
Step 5
36:39
Action Potential Transmission
39:04
Action Potential Transmission
39:05
Speed of Conduction
41:19
Saltatory Conduction
42:58
The Synapse
44:17
The Synapse: Presynaptic & Postsynaptic Cell
44:31
Examples of Neurotransmitters
50:05
Brain Structure
51:57
Meniges
52:19
Cerebrum
52:56
Corpus Callosum
53:13
Gray & White Matter
53:38
Cerebral Lobes
55:35
Cerebellum
56:00
Brainstem
56:30
Medulla
56:51
Pons
57:22
Midbrain
57:55
Thalamus
58:25
Hypothalamus
58:58
Ventricles
59:51
The Spinal Cord
1:00:29
Sensory Stimuli
1:00:30
Reflex Arc
1:01:41
Example 1: Automatic Nervous System
1:04:38
Example 2: Synaptic Terminal and the Release of Neurotransmitters
1:06:22
Example 3: Volted-Gated Ion Channels
1:08:00
Example 4: Neuron Structure
1:09:26
Musculoskeletal System

39m 29s

Intro
0:00
Skeletal System Types and Function
0:30
Skeletal System
0:31
Exoskeleton
1:34
Endoskeleton
2:32
Skeletal System Components
2:55
Bone
3:06
Cartilage
5:04
Tendons
6:18
Ligaments
6:34
Skeletal Muscle
6:52
Skeletal Muscle
7:24
Sarcomere
9:50
The Sliding Filament Theory
13:12
The Sliding Filament Theory: Muscle Contraction
13:13
The Neuromuscular Junction
17:24
The Neuromuscular Junction: Motor Neuron & Muscle Fiber
17:26
Sarcolemma, Sarcoplasmic
21:54
Tropomyosin & Troponin
23:35
Summation and Tetanus
25:26
Single Twitch, Summation of Two Twitches, and Tetanus
25:27
Smooth Muscle
28:50
Smooth Muscle
28:58
Cardiac Muscle
30:40
Cardiac Muscle
30:42
Summary of Muscle Types
32:07
Summary of Muscle Types
32:08
Example 1: Contraction and Skeletal Muscle
33:15
Example 2: Skeletal Muscle and Smooth Muscle
36:23
Example 3: Muscle Contraction, Bone, and Nonvascularized Connective Tissue
37:31
Example 4: Sarcomere
38:17
The Immune System

1h 24m 28s

Intro
0:00
The Lymphatic System
0:16
The Lymphatic System Overview
0:17
Function 1
1:23
Function 2
2:27
Barrier Defenses
3:41
Nonspecific vs. Specific Immune Defenses
3:42
Barrier Defenses
5:12
Nonspecific Cellular Defenses
7:50
Nonspecific Cellular Defenses Overview
7:53
Phagocytes
9:29
Neutrophils
11:43
Macrophages
12:15
Natural Killer Cells
12:55
Inflammatory Response
14:19
Complement
18:16
Interferons
18:40
Specific Defenses - Acquired Immunity
20:12
T lymphocytes and B lymphocytes
20:13
B Cells
23:35
B Cells & Humoral Immunity
23:41
Clonal Selection
29:50
Clonal Selection
29:51
Primary Immune Response
34:28
Secondary Immune Response
35:31
Cytotoxic T Cells
38:41
Helper T Cells
39:20
Major Histocompatibility Complex Molecules
40:44
Major Histocompatibility Complex Molecules
40:55
Helper T Cells
52:36
Helper T Cells
52:37
Mechanisms of Antibody Action
59:00
Mechanisms of Antibody Action
59:01
Opsonization
1:00:01
Complement System
1:01:57
Classes of Antibodies
1:02:45
IgM
1:03:01
IgA
1:03:17
IgG
1:03:53
IgE
1:04:10
Passive and Active Immunity
1:05:00
Passive Immunity
1:05:01
Active Immunity
1:07:49
Recognition of Self and Non-Self
1:09:32
Recognition of Self and Non-Self
1:09:33
Self-Tolerance & Autoimmune Diseases
1:10:50
Immunodeficiency
1:13:27
Immunodeficiency
1:13:28
Chemotherapy
1:13:56
AID
1:14:27
Example 1: Match the Following Terms with their Descriptions
1:15:26
Example 2: Three Components of Non-specific Immunity
1:17:59
Example 3: Immunodeficient
1:21:19
Example 4: Self-tolerance and Autoimmune Diseases
1:23:07
Section 11: Animal Reproduction and Development
Reproduction

1h 1m 41s

Intro
0:00
Asexual Reproduction
0:17
Fragmentation
0:53
Fission
1:54
Parthenogenesis
2:38
Sexual Reproduction
4:00
Sexual Reproduction
4:01
Hermaphrodite
8:08
The Male Reproduction System
8:54
Seminiferous Tubules & Leydig Cells
8:55
Epididymis
9:48
Seminal Vesicle
11:19
Bulbourethral
12:37
The Female Reproductive System
13:25
Ovaries
13:28
Fallopian
14:50
Endometrium, Uterus, Cilia, and Cervix
15:03
Mammary Glands
16:44
Spermatogenesis
17:08
Spermatogenesis
17:09
Oogenesis
21:01
Oogenesis
21:02
The Menstrual Cycle
27:56
The Menstrual Cycle: Ovarian and Uterine Cycle
27:57
Summary of the Ovarian and Uterine Cycles
42:54
Ovarian
42:55
Uterine
44:51
Oxytocin and Prolactin
46:33
Oxytocin
46:34
Prolactin
47:00
Regulation of the Male Reproductive System
47:28
Hormones: GnRH, LH, FSH, and Testosterone
47:29
Fertilization
50:11
Fertilization
50:12
Structures of Egg
50:28
Acrosomal Reaction
51:36
Cortical Reaction
53:09
Example 1: List Three Differences between Spermatogenesis and oogenesis
55:36
Example 2: Match the Following Terms to their Descriptions
57:34
Example 3: Pregnancy and the Ovarian Cycle
58:44
Example 4: Hormone
1:00:43
Development

50m 5s

Intro
0:00
Cleavage
0:31
Cleavage
0:32
Meroblastic
2:06
Holoblastic Cleavage
3:23
Protostomes
4:34
Deuterostomes
5:13
Totipotent
5:52
Blastula Formation
6:42
Blastula
6:46
Gastrula Formation
8:12
Deuterostomes
11:02
Protostome
11:44
Ectoderm
12:17
Mesoderm
12:55
Endoderm
13:40
Cytoplasmic Determinants
15:19
Cytoplasmic Determinants
15:23
The Bird Embryo
22:52
Cleavage
23:35
Blastoderm
23:55
Primitive Streak
25:38
Migration and Differentiation
27:09
Extraembryonic Membranes
28:33
Extraembryonic Membranes
28:34
Chorion
30:02
Yolk Sac
30:36
Allantois
31:04
The Mammalian Embryo
32:18
Cleavage
32:28
Blastocyst
32:44
Trophoblast
34:37
Following Implantation
35:48
Organogenesis
37:04
Organogenesis, Notochord and Neural Tube
37:05
Induction
40:15
Induction
40:39
Fate Mapping
41:40
Example 1: Processes and Stages of Embryological Development
42:49
Example 2: Transplanted Cells
44:33
Example 3: Germ Layer
46:41
Example 4: Extraembryonic Membranes
47:28
Section 12: Animal Behavior
Animal Behavior

47m 48s

Intro
0:00
Introduction to Animal Behavior
0:05
Introduction to Animal Behavior
0:06
Ethology
1:04
Proximate Cause & Ultimate Cause
1:46
Fixed Action Pattern
3:07
Sign Stimulus
3:40
Releases and Example
3:55
Exploitation and Example
7:23
Learning
8:56
Habituation, Associative Learning, and Imprinting
8:57
Habituation
10:03
Habituation: Definition and Example
10:04
Associative Learning
11:47
Classical
12:19
Operant Conditioning
13:40
Positive & Negative Reinforcement
14:59
Positive & Negative Punishment
16:13
Extinction
17:28
Imprinting
17:47
Imprinting: Definition and Example
17:48
Social Behavior
20:12
Cooperation
20:38
Agonistic
21:37
Dorminance Heirarchies
23:23
Territoriality
24:08
Altruism
24:55
Communication
26:56
Communication
26:57
Mating
32:38
Mating Overview
32:40
Promiscuous
33:13
Monogamous
33:32
Polygamous
33:48
Intrasexual
34:22
Intersexual Selection
35:08
Foraging
36:08
Optimal Foraging Model
36:39
Foraging
37:47
Movement
39:12
Kinesis
39:20
Taxis
40:17
Migration
40:54
Lunar Cycles
42:02
Lunar Cycles
42:08
Example 1: Types of Conditioning
43:19
Example 2: Match the Following Terms to their Descriptions
44:12
Example 3: How is the Optimal Foraging Model Used to Explain Foraging Behavior
45:47
Example 4: Learning
46:54
Section 13: Ecology
Biomes

58m 49s

Intro
0:00
Ecology
0:08
Ecology
0:14
Environment
0:22
Integrates
1:41
Environment Impacts
2:20
Population and Distribution
3:20
Population
3:21
Range
4:50
Potential Range
5:10
Abiotic
5:46
Biotic
6:22
Climate
7:55
Temperature
8:40
Precipitation
10:00
Wind
10:37
Sunlight
10:54
Macroclimates & Microclimates
11:31
Other Abiotic Factors
12:20
Geography
12:28
Water
13:17
Soil and Rocks
13:48
Sunlight
14:42
Sunlight
14:43
Seasons
15:43
June Solstice, December Solstice, March Equinox, and September Equinox
15:44
Tropics
19:00
Seasonability
19:39
Wind and Weather Patterns
20:44
Vertical Circulation
20:51
Surface Wind Patterns
25:18
Local Climate Effects
26:51
Local Climate Effects
26:52
Terrestrial Biomes
30:04
Biome
30:05
Forest
31:02
Tropical Forest
32:00
Tropical Forest
32:01
Temperate Broadleaf Forest
32:55
Temperate Broadleaf Forest
32:56
Coniferous/Taiga Forest
34:10
Coniferous/Taiga Forest
34:11
Desert
36:05
Desert
36:06
Grassland
37:45
Grassland
37:46
Tundra
40:09
Tundra
40:10
Freshwater Biomes
42:25
Freshwater Biomes: Zones
42:27
Eutrophic Lakes
44:24
Oligotrophic Lakes
45:01
Lakes Turnover
46:03
Rivers
46:51
Wetlands
47:40
Estuary
48:11
Marine Biomes
48:45
Marine Biomes: Zones
48:46
Example 1: Diversity of Life
52:18
Example 2: Marine Biome
53:08
Example 3: Season
54:20
Example 4: Biotic vs. Abiotic
55:54
Population

41m 16s

Intro
0:00
Population
0:07
Size 'N'
0:16
Density
0:41
Dispersion
1:01
Measure Population: Count Individuals, Sampling, and Proxymeasure
2:26
Mortality
7:29
Mortality and Survivorship
7:30
Age Structure Diagrams
11:52
Expanding with Rapid Growth, Expanding, and Stable
11:58
Population Growth
15:39
Biotic Potential & Exponential Growth
15:43
Logistic Population Growth
19:07
Carrying Capacity (K)
19:18
Limiting Factors
20:55
Logistic Model and Oscillation
22:55
Logistic Model and Oscillation
22:56
Changes to the Carrying Capacity
24:36
Changes to the Carrying Capacity
24:37
Growth Strategies
26:07
'r-selected' or 'r-strategist'
26:23
'K-selected' or 'K-strategist'
27:47
Human Population
30:15
Human Population and Exponential Growth
30:21
Case Study - Lynx and Hare
31:54
Case Study - Lynx and Hare
31:55
Example 1: Estimating Population Size
34:35
Example 2: Population Growth
36:45
Example 3: Carrying Capacity
38:17
Example 4: Types of Dispersion
40:15
Communities

1h 6m 26s

Intro
0:00
Community
0:07
Ecosystem
0:40
Interspecific Interactions
1:14
Competition
2:45
Competition Overview
2:46
Competitive Exclusion
3:57
Resource Partitioning
4:45
Character Displacement
6:22
Predation
7:46
Predation
7:47
True Predation
8:05
Grazing/ Herbivory
8:39
Predator Adaptation
10:13
Predator Strategies
10:22
Physical Features
11:02
Prey Adaptation
12:14
Prey Adaptation
12:23
Aposematic Coloration
13:35
Batesian Mimicry
14:32
Size
15:42
Parasitism
16:48
Symbiotic Relationship
16:54
Ectoparasites
18:31
Endoparasites
18:53
Hyperparisitism
19:21
Vector
20:08
Parasitoids
20:54
Mutualism
21:23
Resource - Resource mutualism
21:34
Service - Resource Mutualism
23:31
Service - Service Mutualism: Obligate & Facultative
24:23
Commensalism
26:01
Commensalism
26:03
Symbiosis
27:31
Trophic Structure
28:35
Producers & Consumers: Autotrophs & Heterotrophs
28:36
Food Chain
33:26
Producer & Consumers
33:38
Food Web
39:01
Food Web
39:06
Significant Species within Communities
41:42
Dominant Species
41:50
Keystone Species
42:44
Foundation Species
43:41
Community Dynamics and Disturbances
44:31
Disturbances
44:33
Duration
47:01
Areal Coverage
47:22
Frequency
47:48
Intensity
48:04
Intermediate Level of Disturbance
48:20
Ecological Succession
50:29
Primary and Secondary Ecological Succession
50:30
Example 1: Competition Situation & Outcome
57:18
Example 2: Food Chains
1:00:08
Example 3: Ecological Units
1:02:44
Example 4: Disturbances & Returning to the Original Climax Community
1:04:30
Energy and Ecosystems

57m 42s

Intro
0:00
Ecosystem: Biotic & Abiotic Components
0:15
First Law of Thermodynamics & Energy Flow
0:40
Gross Primary Productivity (GPP)
3:52
Net Primary Productivity (NPP)
4:50
Biogeochemical Cycles
7:16
Law of Conservation of Mass & Biogeochemical Cycles
7:17
Water Cycle
10:55
Water Cycle
10:57
Carbon Cycle
17:52
Carbon Cycle
17:53
Nitrogen Cycle
22:40
Nitrogen Cycle
22:41
Phosphorous Cycle
29:34
Phosphorous Cycle
29:35
Climate Change
33:20
Climate Change
33:21
Eutrophication
39:38
Nitrogen
40:34
Phosphorous
41:29
Eutrophication
42:55
Example 1: Energy and Ecosystems
45:28
Example 2: Atmospheric CO2
48:44
Example 3: Nitrogen Cycle
51:22
Example 4: Conversion of a Forest near a Lake to Farmland
53:20
Section 14: Laboratory Review
Laboratory Review

2h 4m 30s

Intro
0:00
Lab 1: Diffusion and Osmosis
0:09
Lab 1: Diffusion and Osmosis
0:10
Lab 1: Water Potential
11:55
Lab 1: Water Potential
11:56
Lab 2: Enzyme Catalysis
18:30
Lab 2: Enzyme Catalysis
18:31
Lab 3: Mitosis and Meiosis
27:40
Lab 3: Mitosis and Meiosis
27:41
Lab 3: Mitosis and Meiosis
31:50
Ascomycota Life Cycle
31:51
Lab 4: Plant Pigments and Photosynthesis
40:36
Lab 4: Plant Pigments and Photosynthesis
40:37
Lab 5: Cell Respiration
49:56
Lab 5: Cell Respiration
49:57
Lab 6: Molecular Biology
55:06
Lab 6: Molecular Biology & Transformation 1st Part
55:07
Lab 6: Molecular Biology
1:01:16
Lab 6: Molecular Biology 2nd Part
1:01:17
Lab 7: Genetics of Organisms
1:07:32
Lab 7: Genetics of Organisms
1:07:33
Lab 7: Chi-square Analysis
1:13:00
Lab 7: Chi-square Analysis
1:13:03
Lab 8: Population Genetics and Evolution
1:20:41
Lab 8: Population Genetics and Evolution
1:20:42
Lab 9: Transpiration
1:24:02
Lab 9: Transpiration
1:24:03
Lab 10: Physiology of the Circulatory System
1:31:05
Lab 10: Physiology of the Circulatory System
1:31:06
Lab 10: Temperature and Metabolism in Ectotherms
1:38:25
Lab 10: Temperature and Metabolism in Ectotherms
1:38:30
Lab 11: Animal Behavior
1:40:52
Lab 11: Animal Behavior
1:40:53
Lab 12: Dissolved Oxygen & Aquatic Primary Productivity
1:45:36
Lab 12: Dissolved Oxygen & Aquatic Primary Productivity
1:45:37
Lab 12: Primary Productivity
1:49:06
Lab 12: Primary Productivity
1:49:07
Example 1: Chi-square Analysis
1:56:31
Example 2: Mitosis
1:59:28
Example 3: Transpiration of Plants
2:00:27
Example 4: Population Genetic
2:01:16
Section 15: The AP Biology Test
Understanding the Basics

13m 2s

Intro
0:00
AP Biology Structure
0:18
Section I
0:31
Section II
1:16
Scoring
2:04
The Four 'Big Ideas'
3:51
Process of Evolution
4:37
Biological Systems Utilize
4:44
Living Systems
4:55
Biological Systems Interact
5:03
Items to Bring to the Test
7:56
Test Taking Tips
9:53
Section 16: Practice Test (Barron's 4th Edition)
AP Biology Practice Exam: Section I, Part A, Multiple Choice Questions 1-31

1h 4m 29s

Intro
0:00
AP Biology Practice Exam
0:14
Multiple Choice 1
0:40
Multiple Choice 2
2:27
Multiple Choice 3
4:30
Multiple Choice 4
6:43
Multiple Choice 5
9:27
Multiple Choice 6
11:32
Multiple Choice 7
12:54
Multiple Choice 8
14:42
Multiple Choice 9
17:06
Multiple Choice 10
18:42
Multiple Choice 11
20:49
Multiple Choice 12
23:23
Multiple Choice 13
26:20
Multiple Choice 14
27:52
Multiple Choice 15
28:44
Multiple Choice 16
33:07
Multiple Choice 17
35:31
Multiple Choice 18
39:43
Multiple Choice 19
40:37
Multiple Choice 20
42:47
Multiple Choice 21
45:58
Multiple Choice 22
49:49
Multiple Choice 23
53:44
Multiple Choice 24
55:12
Multiple Choice 25
55:59
Multiple Choice 26
56:50
Multiple Choice 27
58:08
Multiple Choice 28
59:54
Multiple Choice 29
1:01:36
Multiple Choice 30
1:02:31
Multiple Choice 31
1:03:50
AP Biology Practice Exam: Section I, Part A, Multiple Choice Questions 32-63

50m 44s

Intro
0:00
AP Biology Practice Exam
0:14
Multiple Choice 32
0:27
Multiple Choice 33
4:14
Multiple Choice 34
5:12
Multiple Choice 35
6:51
Multiple Choice 36
10:46
Multiple Choice 37
11:27
Multiple Choice 38
12:17
Multiple Choice 39
13:49
Multiple Choice 40
17:02
Multiple Choice 41
18:27
Multiple Choice 42
19:35
Multiple Choice 43
21:10
Multiple Choice 44
23:35
Multiple Choice 45
25:00
Multiple Choice 46
26:20
Multiple Choice 47
28:40
Multiple Choice 48
30:14
Multiple Choice 49
31:24
Multiple Choice 50
32:45
Multiple Choice 51
33:41
Multiple Choice 52
34:40
Multiple Choice 53
36:12
Multiple Choice 54
38:06
Multiple Choice 55
38:37
Multiple Choice 56
40:00
Multiple Choice 57
41:18
Multiple Choice 58
43:12
Multiple Choice 59
44:25
Multiple Choice 60
45:02
Multiple Choice 61
46:10
Multiple Choice 62
47:54
Multiple Choice 63
49:01
AP Biology Practice Exam: Section I, Part B, Grid In

21m 52s

Intro
0:00
AP Biology Practice Exam
0:17
Grid In Question 1
0:29
Grid In Question 2
3:49
Grid In Question 3
11:04
Grid In Question 4
13:18
Grid In Question 5
17:01
Grid In Question 6
19:30
AP Biology Practice Exam: Section II, Long Free Response Questions

31m 22s

Intro
0:00
AP Biology Practice Exam
0:18
Free Response 1
0:29
Free Response 2
20:47
AP Biology Practice Exam: Section II, Short Free Response Questions

24m 41s

Intro
0:00
AP Biology Practice Exam
0:15
Free Response 3
0:26
Free Response 4
5:21
Free Response 5
8:25
Free Response 6
11:38
Free Response 7
14:48
Free Response 8
22:14
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Lecture Comments (14)

0 answers

Post by Haokun Chen on July 12 at 07:37:36 AM

Is the short arm called "p arm" and the long arm called "q arm," and why do they call p and q?

1 answer

Last reply by: Dr Carleen Eaton
Tue Jun 17, 2014 7:34 PM

Post by ido montia on May 19, 2014

thank u so much!! :)

1 answer

Last reply by: Dr Carleen Eaton
Wed Jan 8, 2014 7:29 PM

Post by Yousra Hassan on December 26, 2013

I'm sorry but I don't quiet understand what you mean by "Non-dividing cells". Do they undergo Inter-phase and mitosis and remain with duplicated sets of organelles and genetic material (.etc) contained within one cell? Do they just sort of expand rather than divide?

I apologize if this is a rather dim question but I'm a bit flustered.

Thank you.

1 answer

Last reply by: Dr Carleen Eaton
Wed Jan 8, 2014 7:24 PM

Post by Yousra Hassan on December 26, 2013

I have been taught that G1 and G2 stand for Growth 1 and Growth 2 respectively. Is that incorrect or are they interchangeable ?

Thank you in advance!

1 answer

Last reply by: PATRICIO PORCILE PATRICIO PORCILE
Wed Aug 5, 2015 1:17 PM

Post by Marcus Lind on April 1, 2012

Hi,

Can you explain how the cellcycle for prokaryotic cells are processed?

0 answers

Post by Joel Barrett on October 6, 2011

Your lectures are awesome! I'm actually taking AP Biology right now and there's never enough time to cover all of the material. I also like the medical applications that you have since I am considering going into the medical field.

3 answers

Last reply by: Dr Carleen Eaton
Sat May 28, 2011 10:42 PM

Post by Lisa Ruszkiewicz on May 25, 2011

Dr. Eaton talked about the three checkpoints during the lecture where G1, G2 and M phase. During Example 3 she listed the three checkpoints as G1, S and G2. What are the correct checkpoints?

The Cell Cycle

  • The genetic material (DNA) in eukaryotic cells is organized into chromosomes Chromosomes that have been replicated contain two identical sister chromatids connected by a centromere.
  • The two major phases of the cell cycle are the mitotic phase (M phase) and interphase. Interphase is divided into the G1, S and G2 phases. M phase consists of mitosis and cytokinesis.
  • Cytoplasmic signaling molecules regulate the cell cycle. These molecules constitute the cell cycle control system. Checkpoints occur at G1, G2 and the M phase.
  • Cyclins and cyclin dependent kinases (CDKs) are two types of proteins that regulate the cell cycle. Other internal and external signals also regulate the cell cycle.
  • Cancer cells may not wait for the go-ahead signal at checkpoints in the cell cycle. They also exhibit a loss of density dependent inhibition and anchorage dependence.

The Cell Cycle

Lecture Slides are screen-captured images of important points in the lecture. Students can download and print out these lecture slide images to do practice problems as well as take notes while watching the lecture.

  • Intro 0:00
  • Functions of Cell Division 0:09
    • Overview of Cell Division: Reproduction, Growth, and Repair
    • Important Term: Daughter Cells
  • Chromosome Structure 3:36
    • Chromosome Structure: Sister Chromatids and Centromere
    • Chromosome Structure: Chromatin
    • Chromosome with One Chromatid or Two Chromatids
    • Chromosome Structure: Long and Short Arm
  • Mitosis and Meiosis 7:00
    • Mitosis
    • Meiosis
  • The Cell Cycle 10:43
    • Mitotic Phase and Interphase
  • Cytokinesis 15:51
    • Cytokinesis in Animal Cell: Cleavage Furrow
    • Cytokinesis in Plant Cell: Cell Plate
  • Control of the Cell Cycle 18:28
    • Cell Cycle Control System and Checkpoints
  • Cyclins and Cyclin Dependent Kinases 21:18
    • Cyclins and Cyclin Dependent Kinases (CDKSs)
    • MPF
    • Internal Factor Regulating Cell Cycle
    • External Factor Regulating Cell Cycle
    • Contact Inhibition and Anchorage Dependent
  • Cancer and the Cell Cycle 27:42
    • Cancer Cells
  • Example1: Parts of the Chromosome 30:15
  • Example 2: Cell Cycle 31:50
  • Example 3: Control of the Cell Cycle 33:32
  • Example 4: Cancer and the Cell 35:01

Transcription: The Cell Cycle

Welcome to Educator.com. I am Dr. Carleen Eaton, and today is the first of three lessons on cell reproduction.0000

We are going to start out by talking about the cell cycle.0008

Functions of cell division or cell reproduction include the reproduction of an organism, the growth of an organism and repair.0012

Certain cells of the body, such as those in skin or liver, can actually divide.0022

If you get a cut or an injury, nearby skin cells could divide and help you to heal the same with the liver, so one function of cell division is repair.0028

As we are going to discuss later on, certain very specialized cells, such as neurons, lose their ability to divide, so they can no longer divide and repair in that way.0040

Another function of cell division is reproduction. For example, bacterial cells divide via binary fission.0052

Binary fission is a means of a sexual reproduction, and prokaryotes reproduce via binary fission.0062

Organisms that reproduce sexually create gametes via a particular type of cell division called miosis.0073

Miosis creates gametes such as sperm and egg.0084

Fertilization unites the sperm and egg to create a zygote, which will undergo mitosis, another type of cell division0096

and, thereby, grow into an embryo, a fetus and continue to grow until adulthood.0108

Here, we see reproduction. Cells are reproduced via cell division and growth, so an organism starting out smaller, dividing via mitosis, cell division and specialization of cell types.0115

This is just a general overview, and we are going to go into each type of cell division, miosis, mitosis.0134

And then, later on in the course, when we talk about prokaryotes, I will discuss binary fission.0141

It is important to know some terminology as we go along.0146

When we discuss the cells produced via mitosis and miosis, these are called daughter cells, and mitosis produces a different number of daughter cells than miosis.0149

And again, we will go into all of these details, so remember the term daughter cells, I will use that throughout the course.0162

Another thing to be aware of is that in order for cells to divide, all of the cell's genetic material must be duplicated.0171

In addition, the cytoplasm, organelles, proteins and other components of the cell must be replicated.0181

Duplication of DNA has to occur and does occur in one phase of the cell cycle.0187

And additional organelles, cytoplasm, cell membrane are all made to provide enough material for the daughter cells.0192

Right now, we are going to be focusing on eukaryotic cell division.0203

And since eukaryotes have genetic material that is organized into chromosomes, you need to understand chromosomes and chromosome structure in order to understand cell reproduction.0207

Let's take a look at the structure of chromosomes.0218

The genetic material or DNA in eukaryotic cells is organized into chromosomes, and this actually shows a chromosome that has already had its DNA replicated.0221

And I can tell that because this chromosome consists of two sister chromatids.0234

This is one sister. This whole section is a sister chromatid, and this is the other chromatid, so sister chromatids.0241

The sister chromatids are connected by, what is called a centromere, and the centromere is located here in the middle, so the centromere.0255

And the chromosome, overall, is composed of chromatin, so if you are just looking at...no, what is a chromosome made out of? Chromatin.0271

This is DNA plus protein, so the DNA is actually wound around a special type of protein called histones, so histone proteins plus DNA are known as chromatin.0283

At certain points in the cell cycle, the chromatin becomes very highly condensed.0299

And when it is highly condensed, it is visible via light microscopy in the form that you may have seen photos of, which this shows a sketch of- what a typical chromosome looks like.0305

At other points in the cell cycle, it is just chromatin that is less tightly coiled.0317

Again, here we have a chromosome with two sister chromatids, but I want to point out that if you saw something like this, this is still a complete chromosome.0322

This is one chromosome, and it has only one chromatid on it. This is also considered only one chromosome.0335

It has two chromatids, so it is one chromosome with two chromatids, but these are completely attached; and they are identical.0352

These two chromatids are identical. They contain the same genetic information.0365

So, even though, this has more chromatids, it is still a single chromosome, and this becomes very important when we discuss the differences between miosis and mitosis,0369

understanding that what a chromatid is, what constitutes a chromosome and how many of these that you have, differentiates miosis and mitosis.0380

Again, you start out with a single chromatid on the chromosome. The DNA is replicated at a particular step in the cell cycle, and you will end up with still one chromosome but duplicate information.0392

Each section of the chromosome is called an arm, so this is the short arm.0409

You will hear referred to the short arm of, say, chromosome 20, so the chromosomes are numbered.0414

In humans, in our somatic or most of the cells on our body, other than reproductive cells, are somatic cells, contain 46 chromosomes, and you can hear them called by their number.0419

There is actually 2 sets of 23 chromosome- 2 sets of 23.0431

And this the long arm and the short arm, so the long arm of a particular chromosome, the short arm. This is the long arm and the short arm of its sister chromatid.0440

With that understanding, let's go on and just talk generally about the outcomes of mitosis and miosis, and then, there will be a lecture covering each of these in great detail.0450

Mitosis results in two identical daughter cells, and it conserves the chromosome number.0462

Two types of cell division: one is mitosis, and with mitosis, you will start out with a cell that, let's say, has, for this cell, four chromosomes.0472

Mitosis will occur, and you will end up with daughter cells that have the same number of chromosomes, so conservation of chromosome numbers.0489

In addition, these daughter cells are identical to the parent cells. They are identical in chromosome number.0505

They are also identical in the information that the chromosomes contain. They are identical to each other.0513

They are identical to the parent cell. This is much different than miosis.0518

Miosis occurs to produce gametes, so mitosis produces somatic cells. Somatic cells are all the cells in the body that are not reproductive cells.0525

Liver cells are somatic cells. The cells in your eye, your skin, your kidney, those are all somatic cells.0540

They are just the regular cells of the body.0546

Miosis results in the production of gametes, so gametes are produced via miosis; so miosis produces gametes, in other words, sperm and egg.0550

These are sometimes also called germ cells.0566

In miosis, cells that are going to produce sperm or egg will undergo miosis, and let's say that a particular cell starts out with four chromosomes.0571

With miosis, there is actually two rounds of cell division, and the result will be 1, 2, 3, 4 daughter cells.0588

And each of these, will only have half the number of chromosomes.0602

Here, we started out with 1, 2, 3, 4. Here, I am just going to end up with 1, 2, 1, 2 chromosomes in each, and these are non-identical.0608

Starting out with four chromosomes, ending up with only two, so the daughter cells are non-identical.0623

They are different from each other, and they are different from the parent cells.0634

Let's look at the cell cycle overall because mitosis only takes up a small portion of the cell cycle.0645

There are two major phases in the cell cycle, and the cell actually spends 90% of its time in a phase called interphase, so 90% of its the time in interphase and only 10% in the M phase.0652

Mitosis is part of the M phase, and we talk about mitosis a lot because that is where a lot of the interesting stuff happens.0669

That is when the chromosomes are divided into the daughter cells. However, the cells actually spend most of its time in interphase.0679

Let's first look at the different parts of interphase. There are three parts to interphase: G1, S and G2.0689

G1 stands for Gap 1. S phase is synthesis, and G2 is Gap 2.0696

During interphase, growth occurs, so interphase is growth of the cell, and if the cell is going to divide into daughter cells, as I mentioned before, not only does it need to duplicate its DNA.0711

It needs to make more cytoplasm, proteins, cell membrane components, mitochondria, Golgi apparatus, and that is what is occurring during these phases.0726

During G1, there is growth. There is duplication of organelles, increase in cytoplasm, increase in the size and volume of the cell.0737

The cell moves on to S phase, and I want to be clear that the growth continues.0748

The duplication of the organelles and everything continues, but something else that is very important happens as well.0756

Synthesis S phase, DNA replication occurs.0760

DNA replication occurs, so that there will be enough DNA for each of the daughter cells.0766

After S phase, the cell goes into another gap phase. This one is called G2/Gap 2, and during this time, there is continued growth.0773

The cell will, again, duplicate organelles, continue to increase in size, and then, by the end of Gap 2, the cell has everything it needs to produce daughter cells.0784

This is all interphase, and now, we are in the M phase. There are two portions of M phase: mitosis and cytokinesis.0795

Mitosis is the section of the cell cycle during which the chromosomes are divided up into two separate sets, one for each nuclei of the daughter cell.0804

Here, we have separation of chromosomes. The chromosomes are divided up into two pairs, or not two pairs, two complete sets, one for each nuclei of the daughter cells.0819

Now, cytokinesis is the actual separation of what was one cell into two cells.0840

So now, we have two sets of chromosomes. Everything we need for two cells, but it is still just one cell.0846

The cell pinches off in the middle. The cytoplasm divides, and you end up with two daughter cells.0853

Cytokinesis is the actual physical separation into two cells.0859

Cytokinesis actually starts during late mitosis. It is, sometimes, considered a part of mitosis or telophase.0863

Sometimes, it is written as an extra step afterwards. Either way, it is part of M phase.0871

And you have to remember, these divisions into phases, mitosis or these cytokinesises are arbitray. It is something scientists use to help them discuss and categorize and study the cell cycle.0877

But, in nature, things are more continuous, and there is not these absolute separations.0889

Mitosis and cytokinesis, there is some overlap in these processes.0895

I mentioned before that certain cells such as neurons do not divide.0900

Very highly specialized cell do not divide, so what do they do? Where are they in the cell cycle?0905

Well, they are rested in quiescent phase known as G0. G0 is just a resting state, in which cells do not proceed through the cell cycle.0911

The cells that are in this state or sometimes called post-mitotic cells because G0, that phase is after mitosis.0924

Sometimes, G0 is considered just an extension of the G1. Other times, you will just see it written here as just immediately post mitosis.0933

Either way, G0 is a quiescent resting phase that non-dividing cells stay in.0943

Let's focus a little bit more on cytokinesis. Again, after the cell has duplicated its organelles, duplicated its DNA and then, gone through mitosis, what will happen is,0952

you will have this one cell that is, now, larger than it started out with and two sets of chromosomes, one for what is going to be the nuclei of each daughter cell.0963

But now, these cells need to separate. This cell needs to separate into two daughter cells, and it does that in animals through what is called a cleavage furrow.0976

A cleavage furrow forms down the middle of the cell, and that is this indentation that you see here. This groove is the cleavage furrow.0988

Actin and myosin pinched off the cell in the middle. Remember that actin and myosin are proteins that are also important for the contraction of muscle and for different kinds of movements.1005

One of their functions is to interact in such a way that this cleavage furrow deepens and pinches off, and then, you end up with two physically separate daughter cells- 1, 2, 3, 4, 1, 2 ,3 ,4.1016

And as you will see here, there are four chromosomes, but each only has one chromatid on them; and we will see why in the mitosis lecture.1039

Now, plant cells function a little bit differently as far as cell division, and that is because they have cell walls.1049

Instead of forming a cleavage furrow, what happens with plants is that they form what is called a cell plate.1055

In telophase, vesicles that are formed by the Golgi apparatus start to coil less near the middle of this cell.1064

These vesicle will coil less, and what they contain are components to build a cell wall.1074

This cell plate, then, forms, and a cell wall can be built between what are going to be the two daughter cells; and then, those will divide into two daughter cells.1082

But they stay closely associated with each other, and plants the two daughter cells; and they are actually stuck together.1092

Plant cells, the division is a little bit different. Again, it involves a cell plate versus a cleavage furrow.1101

One very important topic is that of control of the cell cycle because different cells divide at different rates. Certain cells like skin are rapidly dividing.1110

They will go into the cell cycle a couple times in one day even. They have a rapid turnover.1122

Other cells like neurons are rested in one phase of the cell cycle, and if the cell cycle is not tightly controlled, the result will be out of control growth and sometimes cancer.1126

Let's talk about how the cell cycle is regulated.1140

There are cytoplasmic signalling molecules that regulate the cell cycle, and there are also other internal and external factors that regulate the cell cycle,1144

first, focusing on just these cytoplasmic signalling molecules and what is called checkpoints.1152

These molecules constitute what you will hear called a cell cycle control system. Its name tells you what it does - controls or regulates the cell cycle.1158

There are checkpoints in the cell cycle, and these occur at G1, G2 and M phase.1168

Checkpoints are points where the cell stops and waits for a "go ahead" signal.1173

When you look at the cell cycle, that schematic of it, you see that there is G1, S, G2, and you might think that "OK, the cell just moves through".1181

It does G1. It finishes.1191

It goes on to S phase, then, it goes straight to G2; but that is not actually the way it happens.1193

The cell does not automatically move from one phase to the next phase. In fact, it stops after a certain phase.1200

It waits. If it gets a "go ahead" signal, it goes to the next phase.1208

If it does not, it stays there.1214

You can think of this as like a stop light. At these different checkpoints, the cell gets to the checkpoint, the light is red.1217

It waits for a specific signal that is analogous to a green light. When it gets that signal, it goes to the next phase.1225

The most important checkpoint in mammalian cells is the G1 checkpoint. This is often called the restriction point.1233

If a cell receives the "go ahead" signal in the form of these cytoplasmic signalling molecules,1241

the cell will generally advance on through G1, S phase, G2, M phase and end up dividing into two daughter cells.1249

It is very likely if the cell used to go ahead at this point, that it will complete the cycle.1259

If no "go ahead” is given at this restriction point, the cell will stay in G0 quiescent phase and remain there.1265

Alright, what are these cytoplasmic signalling molecules?1274

We know that at least some of them are cyclins and cyclin-dependent kinases.1281

Recall in a previous lecture, I mentioned that kinases are proteins that phosphorylate other proteins, so kinases phosphorylate other proteins.1286

In doing so, these kinases can either activate or deactivate another protein.1304

CDKs/Cyclin-dependent kinases, the name tells you something about them. They are dependent on cyclins.1310

CDKs are cytoplasmic proteins that are inactive until they are bound to cyclin.1316

Active CDKs give the "go ahead" signal at the restriction point and the other checkpoints.1330

These CDKs are existing in the cytoplasm, and when the cyclin interacts with the CDK, the CDK becomes activated.1338

And when that occurs, it can tell the cell, go ahead to the next part of the cycle.1347

Scientists have done experiments in which they have determined that when the level or the concentration of cyclin increases in the cell, CDK activity also increases.1351

Increased cyclin concentration, the result is increased CDK activity, which makes sense if cyclins are necessary to put CDKs in their active form.1362

When the concentration of cyclins decreases, CDK activity decreases as well.1378

OK, there are other internal and external factors, as well, that regulate the cell cycle.1390

To point out also, the first CDK that was discovered that you should actually know the name of is MPF, and this is known as M-phase promoting factor.1398

This is the "go ahead" signal, gives the go ahead at the G2 checkpoint.1413

Now, CDKs and cyclins are necessary for the cell to go through the cell cycle, but they are not sufficient. There are other factors as well.1422

Even if there is a "go ahead", if there is some other factor that is not correct, the cell may not continue to divide.1432

Internal factors: let me give you an example of an internal factor. An example of an internal factor would be chromosomes lining up, being all lined up correctly at a certain part of mitosis.1441

So, even if the "go ahead" signal is given, everything the cell needs to divide is there, if the chromosomes are not in place, it is not just going to keep going.1453

Internal factors are making sure that everything is in place in the correct order before the cell goes on.1461

Example of an internal factor is cell waits for chromosomes to line up before proceeding with mitosis or miosis. That is an internal factor, something inside the cell.1470

CDKs are internal as well, but they are put in a slightly different class.1488

OK, a second type of factor: external factors. These are things that come from outside the cell, for example, nutrients.1493

Even if the cell gets the "go ahead" signal, if it is in a situation where there is no nutrients, that is probably not a good time to divide1501

because there will not be enough nutrients to support the daughter cells.1507

Growth factors: growth factors are secreted by cells, and they induce other cells to divide.1511

They do not come from within the cell that is going to divide. They come from outside it.1520

One cell secretes a growth factor. This cell secretes a growth factor, and what that is going to do, that growth factor is act on nearby cells and tell them "OK".1524

This is the growth factor, let's say, and it is going to tell this cell over here "divide". That is an external factor.1536

These are factors that tell the cell it is OK to divide. The go ahead signal is given.1543

The internal factors are in place. The external factors are in place, go ahead and divide.1548

Conversely, there are factors which stop cell division.1554

The cell knows that it needs to stop dividing under certain conditions. We talked about if maybe there is not enough nutrients, or the chromosomes are not lined up.1560

But there are other things as well, and two important facts to remember is that there is something called contact inhibition and anchorage dependence.1568

Contact inhibition means that the cell will not divide if the situation is too crowded, so it is inhibited by contact with too many other cells around it.1586

This is also called density-dependent inhibition, and this exists both in the lab in vitro and in a living organism in vivo.1598

If you are working in the lab with cell culture, you will see that the cells will just stop dividing once they reach a certain density.1610

They will not just pile up and pile up, and that is due to contact inhibition.1617

Anchorage dependence means that the cell needs to be attached to a substrate.1620

In the lab, if you are growing cells, the container that you are growing the cells in, the cell is going to attach to.1625

And the cells floating around, will not just be floating around and dividing, they have to be attached.1632

Normal cells exhibit contact inhibition and anchorage dependence meaning that they will not divide if the situation is too crowded.1638

And they will not divide if they are not anchored to something. That is normal cells.1647

Cancer cells lose these controls, so let's talk about cancer cells.1653

First, cancer cells may not necessarily wait for the "go ahead" signal at the checkpoints, so I talked about the "go ahead" signal.1667

They might just plough through and go through the cell cycle and go through it again and not wait to get the "go ahead".1675

That is one way in which cancer cycles do not adhere to the normal regulation of the cell.1681

As I mentioned, they also exhibit a loss of density-dependent inhibition, or this is the same as contact inhibition.1689

Even though they are in a really crowded condition, they will just keep growing.1696

They also lose anchorage-dependence, meaning that they do not need to be attached. They might grow even though they are not attached to a substrate.1701

The result of these various factors is that the cells can form tumors, and cancer, as you know, can also spread.1710

It can spread to nearby sites. It can also spread to distant sites, and this spread to the distant sites of the body is called metastasizing or the cell metastasizes.1721

Metastasis- spread to a distant site.1733

Another thing that cancer cells do is they actually induce blood vessels to grow towards them.1740

So, a tumor will actually somehow induce blood vessels to grow toward it.1747

When that happens, now, those cells have a means to get to other areas of the body, and cancer cells actually use blood vessels and lymphatic vessels to spread.1752

Then, since they do not exhibit anchorage dependence, they do not have to be on a substrate. They will start growing somewhere else in the body.1763

And even if things get crowded, they will still grow, and then, they can spread to areas and damage them.1770

For example, let's say that an individual has breast cancer. She has a tumor in her breast.1776

Some of those cells from the breast cancer can invade bone, so they spread to the bone. They grow there, and can damage the bone and cause fractures.1783

When scientists are studying cancer, one thing that they focus on is how are cancer cells different than normal cells, and here are some ways in which they are different.1793

And later on, when we talk about molecular biology, we will look a little more closely at the molecular level about regulation of genes and how that can affect cancer.1800

Alright, let's do a few examples to reinforce what we have just learned.1816

First of all, example one: label the parts of the chromosome below.1820

What is the complex of DNA and protein of which chromosomes are made called? What is the protein component of this material called?1827

So, parts of the chromosome, well, first of all, I see that there are two sister chromatids here, and each of them has a short arm; and each of them has a long arm.1835

And there are two, there are sister chromatids, so we can label those "sister chromatids".1854

Remember that sister chromatids are connected by what is called a centromere.1866

We have the short arm, the long arm, sister chromatids attached by a centromere.1874

What is the complex of DNA and protein of which chromosomes are made called? What is a chromosome made out of?1881

It is made out of chromatin.1887

What is the protein component of this material called? Remember, chromatin is made of DNA and protein.1893

What is this protein? It is histone protein. Histone proteins plus DNA equals chromatin, and that is what a chromosome is composed of.1898

Example two: the figure below shows a schematic representation of the cell cycle with the G1 phase labelled.1911

Label the remaining phases. What phase are non-dividing cells are rested in?1919

Starting out with the G1 phase, which is a growth phase, it is Gap 1, cells that get the "go ahead" will continue on into the S phase.1924

During the S phase, growth continues, and in addition, DNA is replicated, so it is the synthesis phase, S phase or synthesis.1933

The next phase is G2. This is the second gap phase, Gap 2, and during this phase, growth continues.1943

All of these three together are known as interphase. Remember, the cycle spends the vast majority of its time in the interphase, about 90% of the time.1952

Then, the other 10% of the time is spent in M phase, the mitotic phase.1964

Mitotic phase consists of mitosis, which is the separation of the chromosomes into two groups, one for each of the daughter cell nuclei. That is mitosis.1970

Cytokinesis is the physical division of the parent cell into two daughter cells, and remember, in animal cells, that is via a cleavage furrow. In plant cells, it is via the formation of a cell plate.1982

These are the phases.1997

Now, what phase are non-dividing cells are rested in? These cells are in the G0 phase, a quiescent phase, and they are called sometimes post-mitotic cells.2000

Where are the checkpoints in the cell cycle? There are three: G1, S and G2.2015

And remember that G1 is called the restriction point, and if the cell gets the "go ahead" at G1, there is an excellent chance it is going to make it through the whole cell cycle.2023

What are three means by which the cell cycle is regulated? Well, the first one is cytoplasmic factors, and specifically, these cytoplasmic factors are cyclin and cyclin-dependent kinases or CDKs.2034

That is one way, in which a cell cycle is regulated. It is also regulated by internal factors, and the example I gave was the chromosomes lining up.2054

Everything has to be in place in the correct location for the cell cycle to continue.2064

The third type of factors is external factors. External factors include things like nutrients or the presence of growth factors.2070

Remember that there are also ways in which the cell cycle can be stopped, that it can be stopped by contact inhibition, when things become too crowded.2083

It can be stopped by anchorage dependence, so if there is nothing for the cell to hold on to, there is no substrate, it will not continue to divide.2093

Example four: how does the loss of contact inhibition and anchorage dependence allow cancer cells to spread to other areas of the body?2103

OK, contact inhibition, I just mentioned, should stop a cell from dividing, so if things become too crowded, crowded conditions, normal cells stop dividing.2115

Cancer cells do not. Cancer cells can keep dividing in these conditions.2139

Cancer cells may keep dividing. This allows them to form tumors, so even though it has crowded conditions, cell continues to divide.2144

The second one is anchorage dependence. If there is no substrate for the cell to hold on to, normal cells stop dividing.2156

Cancer cells do not. This allows them to break off, go through to blood stream, travel or metastasize or metastasize and grow in distant sites of the body.2173

They do not need the substrate. They can travel through the bloodstream or the lymphatic vessels, set up elsewhere and divide.2205

And this can form tumors and continue to divide even though it is very crowded to the point that it is damaging the organ.2213

The lack of contact inhibition and anchorage dependence allows cancer cells to spread to other areas of the body, metastasize and form tumors.2222

In addition, one thing to know is that a normal cell will only divide a set number of times. It will only go through the cell cycle, let's say 50 times, and then, it will die.2232

Cancer cells sometimes become immortal. They will divide and divide and divide indefinitely, so we call that immortalizing.2243

And that is another reason that tumors form and cancer spreads, is they have an infinite number or a very high number of cell divisions that they can go through unlike normal cells.2251

That concludes this lesson on the cell cycle.2263

I will see you again soon here at Educator.com.2267