Vapor deposition continues to evolve as a versatile approach to creating biointerfaces that influence bacterial and biofilm characteristics. The cover depicts a 96-well plate inside an initiated chemical vapor deposition (iCVD) reactor, a technique that is gentle enough to nondestructively modify the surface of delicate substrates and create biointerfaces. Such biointerfaces have been investigated extensively for their antifouling and/or antibacterial effects. The cover inset features an antibacterial/antifouling schematic and Pseudomonas aeruginosa attached to a biointerface. More recently, researchers have begun to leverage inherent advantages of vapor deposition techniques to uncover new relationships between bacterial behavior and the physicochemical features of biointerfaces