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Cell Mediated Immunity

  • Hallmarks of T-cell Mediated Immunity
    • Definition of a T-cell
    • Maturation of T-cells and cluster of differentiation
  • Antigen-Presenting Cells
    • Cells whose main function includes presentation
    • Other presenting cells
  • Different Variations of Antigen Presentation
  • Subsets of T-cells and Distinct Pathways
      • Th1, Th2, Th17
  • Cytokines and Chemokines
  • Integration of Innate and Adaptive Immunity

Cell Mediated Immunity

Lecture Slides are screen-captured images of important points in the lecture. Students can download and print out these lecture slide images to do practice problems as well as take notes while watching the lecture.

  1. Intro
    • Adaptive Immunity
      • Cell-Mediated Immunity
      • Hallmarks of Cell-Mediated Immunity
      • The T-Cell
      • T-Cell Maturation
      • Cluster of Differentiation (CD)
      • Cluster of Differentiation (CD)
      • Antigen-Presenting Cells
      • T-Cell Subset: T-Helper Cells
      • T-Cell Subset: Cytotoxic (Killer) T-Cells
      • T-Cell Subset: Cytotoxic (Killer) T-Cells
      • T-Cell Subset: Regulatory T-Cells
      • T-Cell Subset: Regulatory T-Cells
      • Cytokines
      • Chemokines
      • Pulling It All Together
        • Example 1
          • Example 2
            • Example 3
              • Intro 0:00
              • Adaptive Immunity 0:43
              • Cell-Mediated Immunity 1:47
                • Lymphocyte T Cell
                • Antigen-Presenting Cells
                • Subset of T Cells
                • Immune Tolerance
              • Hallmarks of Cell-Mediated Immunity 3:02
                • Primary Actor is the T Lymphocyte
                • Directed at Pathogens That Survive in Phagocytes
                • Based on Activation
                • Induce Apoptosis in Cells Displaying Epitopes of Foreign Antigens
                • Activates Macrophages and Natural Killer Cells
                • Stimulates Cells to Secrete Cytokines That Signal Other Cells of the Humoral and Innate Immune Response
                • Responds to Intracellular Antigens
                • Requires Direct, Cell-to-Cell Contact
              • The T-Cell 7:51
                • Mature in the Thymus
                • Presence of the T-Cell Receptor
                • Important Components
                • Antigen-Presenting Cell
                • Type of Leukocyte
                • Responsible for the Immune Responses That Lead to the Following
              • T-Cell Maturation 13:34
                • Thymocyte
                • Thymopoiesis
                • Thymus Conducts a Testing Process of Positive and Negative Selection
                • Somatic Gene Rearrangement
                • Infinite Number of Configurations That Create TCRs
              • Cluster of Differentiation (CD) 17:27
                • Function
                • Immuno-Phenotyping
              • Cluster of Differentiation (CD) 19:34
                • Nomenclature
                • Example
              • Antigen-Presenting Cells 20:50
                • Antigen Presentation
                • Antigen-Presenting Cells
                • Direct Presentation
                • Cross-Presentation
                • Cross-Dressing
                • Professional
                • Others
                • Contact Between an APC and TCR Stimulates Important Signaling Events
              • T-Cell Subset: T-Helper Cells 25:51
                • Th1
                • Th2
                • Th17
              • T-Cell Subset: Cytotoxic (Killer) T-Cells 31:26
                • CD8+ Cells
                • Target Cells with Antigen
              • T-Cell Subset: Cytotoxic (Killer) T-Cells 32:55
                • Perforin
                • Granzyme
                • Pharmaceuticals are Designed to Alter T-Cell Responses
              • T-Cell Subset: Regulatory T-Cells 37:01
                • Suppress Activation of the Immune System
                • Functions
              • T-Cell Subset: Regulatory T-Cells 39:45
                • Commensal Bacteria
                • Graft/ Transplant
                • Pregnancy
                • Tumors
              • Cytokines 42:46
                • Types of Cytokines
                • Chemical Messengers
                • Functional Classes of Cytokines
              • Chemokines 47:17
                • Chemotaxis
                • Inflammation
                • Homeostatic
                • Antiviral Response
                • Designation
              • Pulling It All Together 49:40
              • Example 1 51:40
              • Example 2 52:51
              • Example 3 54:56