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For more information, please see full course syllabus of Microbiology
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Adaptive Immunity

  • Overview of Adaptive Immunity
  • Development of Acquired Immune Cells
    • B cell characteristics
    • Hallmarks of humoral immunity
  • Progression of Humoral Immune Response
    • Step 1: Antigen recognition
    • Step 2: Clonal expansion
    • Step 3: Differentiation
    • Step 4: Antigen elimination
    • Step 5: Immune memory

Adaptive Immunity

Lecture Slides are screen-captured images of important points in the lecture. Students can download and print out these lecture slide images to do practice problems as well as take notes while watching the lecture.

  • Intro 0:00
  • What is Adaptive Immunity? 0:27
    • Primary Immune Response
    • Initiated by a Dendritic Cell That Ingested a Pathogen
    • Naïve B Cells are Stimulated to Proliferate and Differentiate in Specific Response to the Pathogen
    • Process of Adaptive Immunity
  • Humoral Immunity 3:03
  • Development of Acquired Immune Cells 3:41
  • The B Cell 4:50
    • Produced in the Bone Marrow
    • Outer Surface Contains a Specialized B Cell Receptor
    • Initial Activation
    • Secondary Activation
  • Hallmarks of Humoral Immunity 6:23
    • B Lymphocyte is the Central Cell
    • Antibody-mediated
    • Highly Complex
  • Step 1: Antigen Recognition 7:18
    • B Cells Recognize Extracellular Antigenics
    • Antigens on Pathogen Surfaces
  • Step 2: Clonal Expansion 10:43
    • B Cell Divides
    • Clone
    • Maturation of B Cells
  • Step 3: Differentiation 13:46
    • B Cells Differentiate Into Plasma Cells
    • Plasma Cell Produces and Secrets Antibodies Specific to the Origin Antigen
    • Produce and Secrete Abs Specific to the Original Antigen
    • Antigen Presenting Cells Show Protein Antigens to Helper T Cells
  • Step 4: Antigen Elimination 16:30
    • Newly-Manufactured Antibodies Attach to the Antigen
    • Termination of the Humoral Immune Response
  • Step 5: Immune Memory 18:32
    • Memory B Cells Reside in Bone Marrow
    • High-Affinity Immunoglobulins
    • Survive for Years
    • Respond Rapidly When the Antigen is Seen Again
  • Antibodies 22:34
    • Classes - IgM
  • Example 1 24:51
  • Example 2 26:54
  • Example 3 28:03